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From the randomized controlled trials, “the evidence has been strengthened that fish oil fatty acids can prevent sudden cardiac death in humans, and this may prove to be their major cardiac benefit.”
From the randomized controlled trials, there were no significant associations found between fish oil fatty acids and the reduction of nonfatal MIs.
“If there is a family history of sudden cardiac death, then the supplement should be increased to 1 to 2 g of EPA plus DHA.”
“These n-3 fatty acids are antiarrhythmis and can prevent sudden cardiac death in humans.”
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B
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High n-3 group:
10 capsules
6.6 g/day n-3 PUFA
3 g EPA/2.9 g DHA
Low n-3 group:
3 capsules n-3, 7 capsules of olive oil
2 g/day n-3 PUFA
0.9 g EPA/0.8 g DHA
Placebo group:
10 capsules
Olive oil
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There were no significant differences between the three diet groups in regards to the changes in six heart rate variability indexes from before to after supplementation.
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B
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n-3 fatty acid group:
5.2 g n-3 PUFA
4.3 g EPA and DHA
Placebo group:
Olive oil
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After n-3 polyunsaturated fatty acid treatment, the mean heart rate variability, defined as standard deviation of all normal RR intervals in 24-hour Holter recording, was significantly higher compared to baseline (124 ms vs. 115 ms, p=0.04).
The mean difference in heart rate variability, defined as standard deviation of all normal RR intervals in 24-hour Holter recording, was significantly different after n-3 polyunsaturated fatty acid treatment (mean difference = −8.3, 95% CI −16 to −−1) compared to after the control treatment (mean difference = 9.4, 95% CI −2 to 20, p=0.01).
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A
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