TABLE B-2f Studies on Other Cardiac Indicators


Study Type



Agren et al., 1997*

Randomized Controlled Trial

Men (n=55)

Healthy students

Kuopio, Finland

Follow-up of 15 weeks

Seafood and n-3 supplementation

Cobiac et al., 1991*

Randomized Controlled Trial

Men (n=31)

Aged 30-60 years

Adelaide, South Australia

Mildly hyperlipidemic and normotensive

No history of heart disease, hypertension, bleeding disorders, liver or renal disorders, gout, diabetes, recent cerebrovascular accident, or obesity

No steroids, nonsteroidal anti-inflammatory drugs, aspirin, beta-blockers, allopurinol, or cardiac glycosides

No excessive alcohol intake (>40 g/day) or who smoked >20 cigarettes/day

Follow-up of 8 weeks

Seafood and n-3 supplementation

*Included in Balk E, Chung M, Lichtenstein A, Chew P, Kupelnick B, Lawrence A, DeVine D, Lau J. 2004. Effects of Omega-3 Fatty Acids on Cardiovascular Risk Factors and Intermediate Markers of Cardiovascular Disease. Summary, Evidence Report/Technology Assessment No. 93. (Prepared by the Tufts-New England Medical Center Evidence-based Practice Center, Boston, MA). AHRQ Publication No. 04-E010-1. Rockville, MD: Agency for Healthcare Research and Quality.

** N = Evidence of no association or no clear association; B = Evidence of a benefit.

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