TABLE B-2i Studies on Cancer


Study Type



Stolzenberg-Solomon et al., 2002

Randomized Controlled Trial

Men (n=27,111)

Aged 50-69 years

Southwestern Finland

Smoked ≥5 cigarettes/day

Alpha-tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

No history of malignancy other than nonmelanoma cancer of the skin or carcinoma in situ, severe angina upon exertion, chronic renal insufficiency, liver cirrhosis, chronic alcoholism, receipt of anticoagulant therapy, other medical problems which might limit long-term participation, and current use of supplements containing vitamin E (>20 mg/day), vitamin A (>20,000 IU/day), or beta-carotene (>6 mg/day)

Follow-up of up to 13 years (260,006 person-years)

Seafood; dietary fatty acids

MacLean et al., 2006


Part of a larger systematic literature review

Cohorts (n=20 cohorts; 38 articles)

11 different types of cancer

Seafood; dietary fatty acids

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