Amount

Results

Conclusion*

Total energy, n-6 PUFA, n-3 PUFA, fish as continuous variables

Tertiles of n-3 fatty acids intake:

Low = 0.0-37.5 mg/day

Medium = 37.5-155.5 mg/day

High = 155.5-2110.5 mg/day

No significant differences in the change in daily intake of total energy, n-6 PUFA, n-3 PUFA, or fish from 1985-1990 were found between those with normal and impaired cognitive function.

Those with normal cognitive function had significantly higher mean daily intakes of energy (p=0.03), DHA (p=0.05), and fish (p=0.02); and significantly lower mean daily intakes of total fat (p=0.02), total PUFA (p=0.002), and LA (p=0.006) than those with impaired cognitive function.

The adjusted OR for prevalent cognitive impairment are OR=1.09 (95% CI 0.65-1.80) for medium n-3 fatty acid intake and OR=0.96 (95% CI 0.57-1.62) for high n-3 fatty acid intake compared to the low n-3 fatty acid intake (p for trend = 0.9). They are not significant.

The adjusted OR for cognitive decline are OR=0.85 (95% CI 0.40-1.82) for medium n-3 fatty acid intake and OR=0.78 (95% CI 0.35-1.73) for high n-3 fatty acid intake compared to the low n-3 fatty acid intake (p for trend = 0.5). They are not significant.

N

100 g increments of intake/day

After adjusting for total energy and BMI, every 100 g increase in daily fish intake decreases the risk of multiple sclerosis (OR=0.91, 95% CI 0.78-1.05). For males this statistic is 1.08 (95% CI 0.84-1.40), and for females this statistic is 0.83 (95% CI 0.69-1.00).

B (females only)



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