Potential Long-Term Outcomes in Adults with Clinical Disease

Disease or Syndrome

Acute Syndrome(s) in Adults

Disease(s), Syndrome(s), or Clinical Features

Frequency of Occurrence of Outcomesa

Delay Between Acute Infection and Onset of Outcomesb

 

 

Osteomyelitis; cardiovascular, splenic, renal, hepatic, respiratory, nervous system, other abscesses

Rare

Yes (weeks to years)

 

 

Sepsis or infection-related organ damage

Very rare

No

 

 

Chronic meningitis and meningoencephalitis

Very rare

Yes (weeks to years)

 

 

Eye involvement (including uveitis)

Very rare

Yes (weeks to years)

Enteric fever

(typhoid fever, Salmonella enterica serovar Typhi; paratyphoid fever, S. enterica serovars Paratyphi A, B, C)

Fever, bacteremia, headache, lymphadenopathy, enlarged liver or spleen, encephalopathy, intestinal rupture and hemorrhage

Endovascular infection

Rare

No

Postinfection enteropathyd

Rare

No

Sepsis or infection-related organ damage

Rare

No

Chronic intestinal carriage

Rare

Yes (months to years)

Infection of gall bladder or gall stones

Rare

Yes (months to years)

Focal infections or abscesses

Very rare

Yes (weeks to months)

Helicobacter pylori infection

Usually asymptomatic; occasionally gastritis

Atrophic gastritis

Common

Yes (years to decades)

 

 

Duodenal ulcer disease

Rare

Yes (months to years)

 

 

Gastric ulcer disease

Rare

Yes (months to years)

 

 

Gastric cancer

Very rare

Yes (years to decades)

Plague

(Yersinia pestis)

Bubonic plague: sudden onset of high fever, enlarged and tender lymph nodes; patchy bleeding under skin, may progress to pneumonia or septicemic forms

Sepsis or infection-related organ damage

Frequent

No

Pneumonic plague: headache, fever, malaise, muscle pain, pneumonia with cough and bloody sputum; often terminates in respiratory collapse, hemodynamic collapse, death

Sepsis or infection-related organ damage

Frequent

No



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement