Potential Long-Term Outcomes in Adults with Clinical Disease

Disease or Syndrome

Acute Syndrome(s) in Adults

Disease(s), Syndrome(s), or Clinical Features

Frequency of Occurrence of Outcomesa

Delay Between Acute Infection and Onset of Outcomesb

 

disease, urethritis, conjunctivitis

mothers:

 

 

 

In infants born to infected mothers: pneumonia, conjunctivitis

Reactive airways disease

Unknown

Yes (years)

Gonorrhea

(Neisseria gonorrhoeae)

Usually: asymptomatic

Chronic pelvic pain, tubal infertility, ectopic pregnancy

Common in untreated women

Yes (months to years)

Sometimes: cervicitis, pelvic inflammatory disease, urethritis, conjunctivitis

 

 

 

Uncommon: disseminated gonococcal infection (arthritis, tenosynovitis, rash, meningitis, endocarditis)

 

 

 

Of Concern to US troops, but No Evidence of Increased Frequency or Association with Service in Southwest or South-Central Asia

Genital herpes

(herpes simplex virus [HSV])

Usually: asymptomatic

Recurrent genital herpes

Common

Yes (weeks to years)

Sometimes: genital ulcers

(HSV-2)

 

 

 

Uncommon: meningitis, radiculitis

Recurrent meningitis

(Mollaret’s)

Very rare

Yes (weeks to years)

Human immunodeficiency virus Type 1 (HIV-1)

Asymptomatic

Primary infection syndrome (acute retroviral syndrome)

Acquired immune deficiency syndrome (AIDS)

AIDS-related opportunistic infection

Frequent if untreated

Yes (years to decades)

HIV-related malignancies

Common

Yes (years to decades)

Human papillomavirus infection

Asymptomatic

Cervical neoplasia

Rare

Yes (months to years)

Genital warts

Genital squamous cell cancers (penis, anus)

Rare

Yes (years)

Tracheal infection in newborns of infected mothers

Very rare

Yes (months to years)

Human T-cell lymphotropic virus infection (I)

(HTLV-I)

Asymptomatic

Chronic persistent oligoarthritis

Adult T-cell leukemia or lymphoma

Rare

Yes (years)

HTLV-I-associated myelopathy

Rare

Yes (years)



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