Possible adverse effects of pyridoxine (vitamin B₆) supplementation on the inflammatory response

Possible adverse effects of unmetabolized folic acid in the serum

Consideration of genetic variation and relevant parameters in determining the need for individual recommendations for B vitamin requirements.

Selenoprotein P as a possible indicator for setting the EAR for selenium

Health risks associated with marginal selenium intake

Benefits of supplemental selenium as related to selenium status

Mechanisms responsible for selenium's health effects

The alpha-tocopherol, gamma-tocopherol, and delta-tocopherol contents of foods

Biological activity of various vitamin E forms in humans

The dose-dependence of carotenoid effects on health

Effects of polymorphisms on the efficacy of antioxidant nutrients

The role of oxidative stress in chronic disease development of biomarkers of oxidative stress

Relationships of increased risk for oxidative stress (caused by smoking, intense physical activity, high altitude, and genetic predisposition) to requirements for antioxidant nutrients

Predictive value of markers of oxidative stress for clinical end points

Subgroup effects, smoking especially, which persist for antioxidant nutrients

Should antioxidant nutrients be addressed more comprehensively for DRIs?

Risk and benefit curves for lutein, zeaxanthin, lycopene, and selenium chemical species and modulators for possible use in setting DRIs

Roles of vitamin K in coronary artery disease and in brain function

Human studies to examine links of neuropsychological outcome measures or other measures of cognitive function with vitamin K status