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  • Possible adverse effects of pyridoxine (vitamin B6) supplementation on the inflammatory response

  • Possible adverse effects of unmetabolized folic acid in the serum

  • Consideration of genetic variation and relevant parameters in determining the need for individual recommendations for B vitamin requirements.

Antioxidant Nutrients

  • Selenoprotein P as a possible indicator for setting the EAR for selenium

  • Health risks associated with marginal selenium intake

  • Benefits of supplemental selenium as related to selenium status

  • Mechanisms responsible for selenium's health effects

  • The alpha-tocopherol, gamma-tocopherol, and delta-tocopherol contents of foods

  • Biological activity of various vitamin E forms in humans

  • The dose-dependence of carotenoid effects on health

  • Effects of polymorphisms on the efficacy of antioxidant nutrients

  • The role of oxidative stress in chronic disease development of biomarkers of oxidative stress

  • Relationships of increased risk for oxidative stress (caused by smoking, intense physical activity, high altitude, and genetic predisposition) to requirements for antioxidant nutrients

  • Predictive value of markers of oxidative stress for clinical end points

  • Subgroup effects, smoking especially, which persist for antioxidant nutrients

  • Should antioxidant nutrients be addressed more comprehensively for DRIs?

  • Risk and benefit curves for lutein, zeaxanthin, lycopene, and selenium chemical species and modulators for possible use in setting DRIs

Micronutrients

  • Roles of vitamin K in coronary artery disease and in brain function

  • Human studies to examine links of neuropsychological outcome measures or other measures of cognitive function with vitamin K status



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