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  • A disease prevention approach that involves targeting the molecular antecedents of disease, such as molecular antecedents for cancer

  • If a nutrient has beneficial effects at doses much higher than needed for the prevention of deficiency, how should this affect the setting of EARs and RDAs?

  • If a nutrient prevents an adverse outcome in one subgroup but not in another, how can this information be incorporated into a DRI process?

  • Should the concept of a range of nutrient intake be reconsidered, or is there some other method to incorporate information about disease prevention (including subgroup-specific information) into the DRI process?

  • Development of a standard approach for setting an AI

  • Should an Adequate Intake (AI) be set for a nutrient that has no known essential functions in humans?

  • Can the process of setting ULs be made more systematic—one that consistently uses a decision tree approach?

  • Could risk assessment methodology be used to evaluate the lower end rather than just the upper end of nutrient risk?

  • New concerns for ULs related to epigenetic effects and genetic rescue

  • Can the UL concept be expanded to include a numerical value for nutrients for which an adverse effect or a toxicity has not been clearly established?

  • Are separate UL values needed for different forms of a nutrient?

  • Methods to apply the DRI process to chronic diseases

  • The meaning of “healthy population” in relation to setting DRIs

  • Setting ULs for nutrients for which there is a direct progressive relationship between intake and occurrence and/or severity of the adverse effect but for which there is no threshold

  • Criteria and methods for adjusting nutrient recommendations, as for age, size

  • A basis for expressing DRIs as densities or ratios

  • Consumer communication research

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