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Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
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D
Glossary

adhesion — an abnormal band of tissue that can grow in the body, typically as a side effect of surgery, and cause two adjoining bodies to stick together

adult stem cell — a type of undifferentiated cell found in children and adults that has the ability to divide indefinitely and to generate all the different cell types found in the organ from which it comes; it has been suggested that adult stem cells could be used to regenerate organs

androgen — any of the various male sex hormones, including testosterone

antibody — a protein used by the immune system to fight infection by identifying and helping to neutralize the infecting agents, such as bacteria or viruses

antral follicle — a follicle in the final stage before ovulation

ascites — an accumulation of fluid in the abdomen between the abdominal wall and the internal organs, that is, in the peritoneal cavity

aseptic — sterile; free of germs

assisted reproductive technology (ART) — a medical treatment for infertility, such as in vitro fertilization

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

atresia — the process by which an immature follicle degenerates and is reabsorbed by the body

blastocyst — an early-stage embryo containing between 50 and 150 cells; its inner cell mass often serves as the source for embryonic stem cells

capnography — a technique for monitoring the levels of carbon dioxide being inhaled and exhaled, thus giving an indirect measure of blood carbon dioxide levels

clomiphene — a fertility drug that acts by inhibiting the action of estrogen on the pituitary gland, stimulating the gland to release more follicle-stimulating hormone

creatinine — a molecule formed in muscle tissue as a byproduct of the breakdown of creatine phosphate

desaturation — a lowering of the oxygen content of the blood

embryo — the product of a fertilized egg and its ongoing development from the time it implants itself in the uterus (at five to seven days after fertilization) until the eighth week of development, after which it is considered a fetus

embryonic stem cell — a stem cell that can give rise to any type of cell in the body; it is derived from the inner cell mass of a blastocyst, an embryo that is four to five days into development

endometrioma — a cyst in the ovary caused by the presence of endometrial tissue, that is, tissue similar to the lining of the uterus

endometriosis — a medical condition caused by tissue like that of the lining of the uterus (endometrium) being found elsewhere in the body; the symptoms include internal bleeding, inflammation, formation of scar tissue, and interference with the normal functioning of the surrounding tissue

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

estradiol — the major female sex hormone; it plays many roles, including serving as the trigger for the surge of luteinizing hormone that induces ovulation

estrogen — any of various female sex hormones, including estradiol

estrogen receptor — a protein on the surface of a cell or inside it that binds to an estrogen molecule and, in response to its presence, sets in motion various activities within the cell, such as the production of certain proteins

fallopian tube — a thin tube that carries eggs from the ovaries to the uterus

fertility drugs — generally speaking, any medication that increases fertility, but most often used to denote drugs that stimulate the development of follicles in the ovary

follicle — the roughly spherical structure in the ovary that contains the oocyte

follicle-stimulating hormone (FSH) — a hormone secreted by the pituitary gland that acts in the ovaries to stimulate the maturation of follicles

follicular sac — a fluid-filled portion of the follicle that contains the oocyte

gonadotropin — a general type of hormone secreted by the pituitary gland; specific types of gonadotropins include luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin

gonadotropin-releasing hormone (GnRH) — a hormone produced by the hypothalamus that triggers the release of luteinizing hormone and follicle-stimulating hormone from the pituitary gland

gonadotropin-releasing hormone agonist — a synthetic hormone designed to act on the same receptors that gonadotropin-releasing hormone acts on and thus to cause a similar effect

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

hemoconcentration — a decrease in blood volume that leads to an increased concentration of red blood cells

hormone — a substance that acts as chemical messenger in the body, being produced in one place and traveling through the bloodstream to trigger some action in another

human chorionic gonadotropin (hCG) — a hormone produced by the developing embryo to promote the development of the corpus luteum and, ultimately, to help prepare the lining of the uterus for the fetus; because of its chemical similarity to luteinizing hormone, it is often used during a course of ovarian stimulation to induce ovulation

hyperstimulation — see ovarian hyperstimulation syndrome

hypogastric artery — the main artery of the pelvis, supplying blood to the pelvic area, the buttocks, and the reproductive organs; also known as the internal iliac artery

in vitro fertilization (IVF) — a technique used in infertility treatments and in research by which an egg is fertilized outside the body

inhibin b — a hormone that inhibits the synthesis and secretion of follicle-stimulating hormone; it is thought to be released by a dominant follicle to cause the pituitary gland to produce less follicle-stimulating hormone and so cause competing follicles to stop growing

inner cell mass — the group of cells on the inside of a blastocyst that contains the embryonic stem cells

luteinizing hormone (LH) — a hormone produced by the pituitary gland that triggers ovulation when its levels spike

meta-analysis — a technique for combining the data and results from a number of different studies addressing the same or similar questions and using those combined studies to come to a conclusion that can be more trustworthy than the results of any single one of the individual studies

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

mittelschmerz — a lower abdominal or pelvic pain felt by some women midway through their menstrual cycle, or around the time of ovulation

myoma — a type of tumor, the most common of which is the uterine fibroid, which grows in the uterus

nociceptors —nerve endings in the skin, muscle, and internal organs that are responsible for the sensation of pain

oocyte — the female germ cell that, after it matures, can be fertilized by a sperm cell to create an embryo; an ovum or egg before maturation

ovarian hyperstimulation syndrome (OHSS) — a possible complication of ovarian stimulation; symptoms include increased ovarian size, nausea and vomiting, increased permeability of the blood vessels, leading to an accumulation of fluid in the abdomen, breathing difficulties, hemoconcentration, and, in the most severe cases, blood clots or kidney failure

ovarian stimulation — the use of fertility drugs to rescue eggs that would otherwise be lost in a monthly cycle and cause an elevated number of mature eggs to be available in the ovary

ovarian torsion — a situation in which the ovary twists around on itself, cutting off its blood supply

ovulation — the rupture of a mature follicle and release of its egg

paracervical block — a type of anesthesia sometimes used during childbirth that involves injecting a local anesthetic on either side of the cervix

pelvic abscess — a collection of pus that forms in a cavity in the pelvic region in response to infection or the presence of a foreign object

pelvic inflammatory disease (PID) — an inflammation of the female reproductive tract, including the uterus, fallopian tubes, and ovaries, caused by an infection and whose symptoms can include fever, ab-

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

dominal pain, and abnormal discharge; it is the leading cause of sterility among women

perineum — in females, the surface region between the pubic bones and the coccyx (tailbone), containing the vagina and the anus

peritoneum — the membrane that lines the abdominal cavity

peritonitis — an inflammation of the peritoneum

pituitary apoplexy — a bleeding within the pituitary gland that can cause headache, confusion, and loss of consciousness

pituitary gland — a gland at the base of the brain that secretes hormones that are involved in regulating a number of body functions, including growth, blood pressure, and the production of eggs

polycystic ovarian syndrome (PCOS) — an endocrine disorder characterized by multiple cysts in the ovaries, irregular or missing ovulation, and a higher-than-usual level of androgens

primordial follicle — a follicle that has not begun development toward a mature follicle

progesterone — a hormone that plays a number of roles in the menstrual cycle and pregnancy

pulse oximetry — a technique for measuring the oxygenation of blood by passing infrared light through a finger, ear lobe, or other thin part of the anatomy

somatic cell nuclear transfer — the process of taking the nucleus from a somatic cell (a cell other than a sperm or an egg cell) and putting it into an egg in place of the egg’s own nucleus; since a cell’s DNA is contained in its nucleus, an egg produced by somatic cell nuclear transfer has the genetic material from the donor of the somatic cell; the technique is used in stem cell research to create stem cells that are genetically identical to the donor

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

stem cell — a primal cell that can divide indefinitely and that can differentiate into a number of different types of cells

stem cell therapy — the use of stem cells to treat disease or injury; medical researchers believe that stem-cell-based treatments have the potential to treat a large number of diseases, including chronic heart disease, Type I diabetes, and Parkinson’s disease, as well as many types of injuries, such as spinal cord damage, the brain damage caused by a stroke, and the damage to heart muscles caused by a heart attack.

tamponade — an absorbent dressing used to stop bleeding

thrombophilia — an increased tendency to develop blood clots

torsion — see ovarian torsion

transvaginal probe — an instrument used to retrieve eggs from the ovary

ureter — one of the ducts that carry urine from the kidneys to the bladder

Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

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Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
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Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
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Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 79
Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 80
Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 81
Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 82
Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 83
Suggested Citation:"Appendix D Glossary." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 84
Next: Appendix E Biographical Sketches of Committee Members, Invited Speakers, and Staff »
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It is widely understood that stem cell treatments have the potential to revolutionize medicine. Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells.

For this research to move forward, however, will require a steady supply of stem cells, particularly human embryonic stem cells. Those stem cells are collected from developing human embryos created from eggs—or oocytes—harvested from the ovaries of female donors. Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort.

The oocyte donation process is not without risk, however. Donors are given doses of hormones to trigger the production of more eggs than would normally be produced, and this hormone treatment can have various side effects. Once the eggs have matured in the ovary, they must be retrieved via a surgical procedure that is typically performed under anesthesia, and both the surgery and the anesthesia carry their own risks. Furthermore, given the very personal nature of egg donation, the experience may carry psychological risks for some women as well.

With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006. This report is a summary and synthesis of that workshop.

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