HIPAA Health Insurance Portability and Accountability Act

IOM Institute of Medicine

IP Intellectual property

IRB Institutional Review Board

IVDMIA In Vitro Diagnostic Multivariate Index Assay

MIAME Minimum Information About a Microarray Experiment

MMRC Multiple Myeloma Research Consortium

NBN National Biospecimen Network

NCI National Cancer Institute

NICE U.K. National Institute for Clinical Excellence

NIH National Institutes of Health

NIST National Institute of Standards and Technology

NLA National limitation amount

OBQI Oncology Biomarker Qualification Initiative

PBRC Pharmaceutical Biomedical Research Consortium

PET Positron emission tomography

PMA Premarket approval

PPP Public–private partnerships

PSA Prostate-specific antigen

PSI Protein Structure Initiative

SACGT Secretary’s Advisory Committee on Genetic Testing

SEMATECH Semiconductor Manufacturing Technology

SNP Single nucleotide polymorphism

TRWG Translational Research Working Group

TSC The SNP Consortium

USPSTF U.S. Preventive Services Task Force

GLOSSARY

Allele—any one of a series of two or more different genes that occupy the same position (locus) on a chromosome.

Amplification—a process by which specific genetic material is increased. For some cancers, the number of copies of specific genes is higher than normal. These genes are said to be amplified.

Analyte-specific reagent (ASR)—antibodies, both polyclonal and monoclonal, specific receptor proteins, ligands, nucleic acid sequences, and similar reagents, which through specific binding or chemical reaction with substances in a specimen are intended to be used in a diagnos-



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement