TABLE C-2 Epidemiologic Studies—Environmental Exposure

Reference

Study Design

Description

Study Group (n)

Comparison Group (n)a

Seveso Studies Reviewed in Update 2006

Baccarelli et al., 2005

Population based

Investigate health status of chloracne cases, TCDD-chloracne exposure relationship, and factors modifying TCDD toxicity

101 chloracne cases

211 control

Eskenazi et al., 2005

Population based

Seveso Women’s Health Study examining the relationship of TCDD (serum dioxin) and age at menopause

616

None

Landi et al., 2005

Population based

Effects of CYP1A1, CYP1B1 variant genotypes and haplotypes on mRNA expression and EROD activity in lymphocytes

62

59

Warner et al., 2004

Population based

Examined the age of menarche in SWHS women who were premenarcheal at the time of the explosion

282

 

Seveso Studies Reviewed in Update 2004

Baccarelli et al., 2004

Population based

mRNA concentrations, AhR, ARNT, CYP1A1, CYP1B1 genes, and EROD activity in peripheral blood lymphocytes in a Seveso, Italy cohort

62

59

Eskenazi et al., 2004

Cohort

Relationship between serum TCDD concentration and age at exposure in SWHS participants

899

None

Eskenazi et al., 2003a

Cohort

Association between maternal serum TCDD and birth outcome SWHS participants

888

None

Landi et al., 2003

Population based

Effect of TCDD-mediated alterations in AhR-dependent pathway in Seveso Zone A and B residents

62

59

Baccarelli et al., 2002

Population based

Immunologic effects in Seveso residents, compared with previous published results

62

59



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement