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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the Committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This study was supported by the American Veterinary Medical Association; Aventis Pharmaceuticals; the Bosack-Kruger Foundation; Bristol-Myers Squibb; GlaxoSmithKline; Humane Society of the United States; Scientists Center for Animal Welfare; Wyeth-Ayerst Pharmaceuticals; Department of Agriculture, Animal and Plant Health Inspection Service; and Department of Health and Human Services, National Institutes of Health through Contract Number N01-OD-4-2139 Task Order #161. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the organizations or agencies that provided support for the project. The content of this publication does not necessarily reflect the views or policies of the National Institutes of Health, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government.

Library of Congress Cataloging-in-Publication Data

Recognition and alleviation of distress in laboratory animals / Committee on Recognition and Alleviation of Distress in Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies.

p. ; cm.

Includes bibliographical references and index.

ISBN-13: 978-0-309-10817-1 (pbk.)

ISBN-10: 0-309-10817-9 (pbk.)

1. Laboratory animals—Health. 2. Laboratory animals—Effect of stress on. 3. Animal welfare. I. Institute for Laboratory Animal Research (U.S.). Committee for Recognition and Alleviation of Distress in Laboratory Animals.

[DNLM: 1. Animal Welfare—standards. 2. Animals, Laboratory. 3. Laboratory Animal Science—ethics. QY 54 R307 2008]

SF406R43 2008

636.088’5—dc22

2007052927

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