FIGURE 3-4 Correlations between striatal D2R and brain glucose metabolism.

NOTE: Orbitofrontal cortex (OFC); dopamine (DA).

SOURCE: Volkow et al., 2004.

transgene in the striatum during a restricted period in fetal development (Kellendonk et al., 2006). Yet they found that abnormalities in dopaminergic function in the prefrontal cortex persisted well into adulthood—long after the transgene had been turned off. This study—and others soon to be published regarding cocaine distribution to the fetus from maternal use—raises the possibility of lifelong structural and functional effects on brain neurocircuitry as a result of fetal exposure to drugs of abuse.

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