FIGURE 2-9 Phylogenetic analysis of West Nile virus E gene sequences, by (A) year and (B) location, United States.

SOURCE: Reprinted from Herring et al. (2007), with permission from Elsevier.

United States. The experience with WNV demonstrates that the epidemiological pattern in areas of importation of an exotic arbovirus may bear little resemblance to that which occurred in its previously endemic area.

WNV has had considerable regional and local variation in incidence and persistence in the United States. Incidence appears to be highest in the midwest-

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