Assessor Blinded?

Baselineb and Change in PTSD Measure

Statistically Significant? (versus control)

Loss of Diagnosis (%)

Principal Limitations

Yes

~52

 

(at 3-month follow-up)

No major limitations

 

−17.3

No

77.77% (of 9)

 

−8.4

No

22.22% (of 9)

 

−14.1

 

 

No (self-report)

66.88, 74.69

 

 

 

−21.12

Yes

87%

29% dropout rate with completers analysis

−1.63

 

41%

NR

No single measure, 8 symptom scales

Yes (on 5 of 8 PRF scales)

NR

Dropout or completer numbers not reported; non-standard, multiple scale PTSD measure and no total reported

Yes

~24–25

(Pre-Tx vs. follow-up)

 

28.6% dropout; method of handling missing data not reported; no adequate treatment of missing data; 28.6% differential dropout

 

 

50%

 

–13.41

Yes

40%

 

−10.34

Yes

90%

 

−6.30

No

100%

 

−4.93

 

eThe authors report that they also tested “mean replacement” to address missing data, yielding results no different from LOCF.

fAnalysis reported for 1-year follow-up only, not reported post-test (change at 1 year: 9.2, −1.1, −4.4).

gThe investigators reported that 3 of 58 dropped out before beginning treatment but after randomization. However, these were not included in the actual reported dropout figure. Also, the number of patients in the control arm was calculated by subtracting 14 + 7 from 55.

hTrauma Symptom Checklist-40.

iFifteen dropped out.

jIn this study CS was used as an active control, not as a treatment arm.

in change from baseline to post-treatment measures for each treatment arm (Brom et al., 1989). The trial of brainwave neurofeedback in Vietnam veterans with chronic PTSD used the Minnesota Multiphasic Personality Inventory (MMPI)-PTSD lacked assessor blinding or independence (Peniston and Kulkosky, 1991). Based on this extremely limited body of evidence, the committee believes that it would be inappropriate to reach a conclusion regarding the efficacy of any of these treatments.



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