TABLE 3-7 Tricyclic Antidepressants

Study

Populationa

Arm (N)

Handling of Dropouts and % Completed Tx by Arm

PTSD Outcome Measure

Kosten et al., 1991

Male, combat

Total (60)

LOCF

IES

Phenelzinec (19)

51.6% overall

Impramine (23)

Not clear

PL (18)

 

Davidson et al., 1990

Male, combat

Total (46)

No treatment of missing values, completer analysis 71% completed 8 weeks overall

IES

Amitriptyline (25)

PL (21)

 

NR

 

NR

Reist et al., 1989

Male, combat

Total (27)d

Completer analysis only

IOE, intrusion (I) and avoidance (A)

Desipramine (NR)

77.7–66.6%e

NR

Crossover Study

 

PL (NR)

NR

aIn the population column, male alone or female alone denotes that at least 80% of the study population was male or female. If only one trauma type is listed, at least 80% of the study population reported that type of trauma.

bPTSD outcome measure change data were obtained either directly from the study, when provided, or by subtracting data reported at treatment completion (not follow-up data) from baseline data (before treatment began). Average baseline score when reported or when baseline

TABLE 3-8 Mirtazapine

Study

Populationa

Arm (N)

Handling of Dropouts and % Completed Tx by Arm

PTSD Outcome Measure

Davidson et al., 2003

Sex NR, mixed

Total (29)

LOCF

SPRINT

Mirtazapine (17)

69% overall

PL (9)

NR

 

NR

aIn the population column, male alone or female alone denotes that at least 80% of the study population was male or female. If only one trauma type is listed, at least 80% of the study population reported that type of trauma.

bPTSD outcome measure change data were obtained either directly from the study, when



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