Emerging Safety Science: Workshop Summary
The following HTML text is provided to enhance online
readability. Many aspects of typography translate only awkwardly to HTML.
Please use the page image
as the authoritative form to ensure accuracy.
it was suggested that a level of transcriptional change greater than 3 percent indicates drug-related pathology. Information gained from studying gene expression changes can be used to
identify toxicological issues early prior to large financial investments;
select the compounds that are least likely to fail because of toxicological issues;
understand mechanisms of toxicity; and
bridge preclinical and clinical data by understanding the mechanisms and commonalities in responses.
These gene expression assays, however, apply only to rat models, and the next challenge is to transition from prediction of toxicity in rats to prediction of toxicity in humans.