Appendix C
Commercially Available Radiopharmaceuticals

Radiopharmaceutical

Trade Name

Primary Uses

Carbon-14 Urea

Pytest

Detection of H Pylori

Cobalt-57 cyanocobalamin

Rubratope

Schilling test

Chromium-51 sodium chromate

Chromitope (Bracco)

Mallinckrodt Cr-51

Labeling red blood cells (RBC)

Fluorine-18-FDG

 

Positron emission tomography (PET) imaging

Gallium-67

Neoscan (GE)

DuPont Ga-67

Mallinckrodt Ga-67

Soft-tissue tumor and inflammatory process imaging

Indium-111 chloride

Indiclor (Nycomed)

Mallinckrodt In-111Cl

Labeling monoclonal antibodies and peptides (OncoScint & Octreoscan)

Indium-111 pentetate (DTPA)

Indium DTPA In-111

Imaging of cerebrospinal fluid kinetics

Indium-111 oxyquinoline (oxine)

Indium-111 oxine

Labeling leukocytes and platelets

Indium-111 Capromab pendetide

ProstaScint

Monoclonal antibody for imaging prostate cancer



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Advancing Nuclear Medicine through Innovation Appendix C Commercially Available Radiopharmaceuticals Radiopharmaceutical Trade Name Primary Uses Carbon-14 Urea Pytest Detection of H Pylori Cobalt-57 cyanocobalamin Rubratope Schilling test Chromium-51 sodium chromate Chromitope (Bracco) Mallinckrodt Cr-51 Labeling red blood cells (RBC) Fluorine-18-FDG   Positron emission tomography (PET) imaging Gallium-67 Neoscan (GE) DuPont Ga-67 Mallinckrodt Ga-67 Soft-tissue tumor and inflammatory process imaging Indium-111 chloride Indiclor (Nycomed) Mallinckrodt In-111Cl Labeling monoclonal antibodies and peptides (OncoScint & Octreoscan) Indium-111 pentetate (DTPA) Indium DTPA In-111 Imaging of cerebrospinal fluid kinetics Indium-111 oxyquinoline (oxine) Indium-111 oxine Labeling leukocytes and platelets Indium-111 Capromab pendetide ProstaScint Monoclonal antibody for imaging prostate cancer

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Advancing Nuclear Medicine through Innovation Radiopharmaceutical Trade Name Primary Uses Indium-111 pentetreotide Octreoscan Imaging neuroendocrine tumors I-123 sodium iodide Mallinckrodt Amersham Thyroid imaging and uptake I-125 iothalamate Glofil Measurement of glomerular filtration I-125 human serum albumin (RISA) Isojex Plasma volume determinations I-131sodium iodide Iodotope (Bracco) CIS - I-131 Mallinckrodt I-131Soln Mallinckrodt I-131 Therapy Caps Mallinckrodt I-131 Diagnostic Caps Thyroid uptake, imaging, and therapy Tositumomab & Iodine I-131 Tositumomab Bexxar Treatment of non-Hodgkin’s lymphoma I-131 iodomethylnorcholesterol (NP-59) (University of Michigan) Adrenal imaging I-131 metaiodobenzylguanidine (MIBG) I-131 MIBG Imaging pheochromocytomas and neuroblastomas P-32 chromic phosphate Phosphocol P32 Therapy for intracavitary malignancies P-32 sodium phosphate   Therapy for polycythemia vera Rubidium-82 (from Sr-82/Rb-82 generator) Cardio-Gen-82 PET imaging Samarium-153 Lexidronam (Sm-153 EDTMP) Quadramet Palliative treatment of bone pain of skeletal metastases Strontium-89 Metastron Palliative treatment of bone pain of skeletal metastases

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Advancing Nuclear Medicine through Innovation Radiopharmaceutical Trade Name Primary Uses Tc-99m pertechnetate Generators DuPont Mallinckrodt DTE Mallinckrodt FM Amersham Imaging thyroid, salivary glands, ectopic gastric mucosa, parathyroid glands, dacryocystography, cystography Tc-99m Apcitide AcuTect Peptide imaging of deep vein thrombosis Tc-99m bicisate (ECD) Neurolite Cerebral perfusion imaging Tc-99m disofenin (DISIDA) Hepatolite-CIS Hepatobiliary imaging Tc-99m exametazine (HMPAO) Ceretec Cerebral perfusion imaging Tc-99m Gluceptate Draximage Mallinckrodt Renal imaging Tc-99m human serum albumin (HSA)   Imaging cardiac chambers Tc-99m macroaggregated albumin (MAA) Pulmolite - CIS Macrotec (Bracco) Technescan MAA (Mallinckrodt) Draximage Amersham MAA Pulmonary perfusion Tc-99m Mebrofenin Choletec Hepatobiliary imaging Tc-99m Medronate (MDP) Bracco Osteolite - CIS Draximage Mallinckrodt Amersham Bone imaging Tc-99m Mertiatide Technescan MAG3 Renal imaging Tc-99m Oxidronate (HDP) Mallinckrodt HDP Bone imaging Tc-99m Pentetate (DTPA) Techneplex (Bracco) CIS-AN DTPA CIS-DTPA Draximage DTPA Mallinckrodt DTPA Nycomed DTPA Renal imaging and function studies; Radioaerosol ventilation imaging

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Advancing Nuclear Medicine through Innovation Radiopharmaceutical Trade Name Primary Uses Tc-99m Pyrophosphate (PYP) Phosphotec (Bracco) Pyrolite-CIS Pyro-CIS Technescan PYP Amersham PYP Avid infarct imaging; in vivo RBC labeling Tc-99m red blood cells Ultratag Imaging gastrointestinal (GI) bleeds, cardiac chambers Tc-99m Sestamibi Cardiolite Miraluma Myocardial perfusion imaging Breast tumor imaging Tc-99m Succimer (DMSA) Amersham DMSA Renal imaging Tc-99m Sulfur Colloid (SC) CIS-Sulfur Colloid Nycomed - SC Imaging liver/spleen, gastric emptying, GI bleeds Tc-99m Tetrofosmin Myoview Myocardial perfusion imaging Thallium-201 DuPont Mallinckrodt Amersham Myocardial perfusion imaging; Parathyroid and tumor imaging Y-90 Ibitumomab Tiuxetan Zevalin non-Hodgkin’s lymphoma Xenon-133 DuPont Xenon Mallinckrodt Xenon Amersham Xenon Pulmonary ventilation imaging Interventional Agents Trade Name Use in nuclear medicine ACD solution (anticoagulant acid Acitrate dextrose) ACD Solution Modified Anticoagulant used in blood labeling Adenosine Adenoscan Pharmacologic stress Ascorbic acid Ascorbic acid RBC labeling and HDP preparation I.V. Dipyridamole I.V. Persantine Pharmacologic stress Sincalide Kinevac Gallbladder ejection fraction studies SOURCE: University of Arkansas for Medical Sciences (http://nuclearpharmacy.uams.edu/resources/PackageInserts.asp).