There is evidence from many controlled studies that exposure to beryllium can cause lung cancer in rats. Epidemiologic studies have reported increases in lung-cancer risk in two worker cohorts exposed to beryllium. Those studies were instrumental in forming the basis of the current cancer classifications by such agencies as the International Agency for Research on Cancer, the U.S. Environmental Protection Agency, and the National Toxicology Program. After the cancer classifications were formed, critiques and alternative analyses of the epidemiologic investigations took place. In its second report, the committee will consider the collective evidence in determining whether any of the available studies are appropriate for establishing carcinogenic risk estimates.

In studies of health end points other than CBD and cancer, adverse effects have generally been observed only at doses higher than the lowest doses that induce CBD or cancer.

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