Questions? Call 800-624-6242
The following HTML text is provided to enhance online
readability. Many aspects of typography translate only awkwardly to HTML.
Please use the page image
as the authoritative form to ensure accuracy.
Health Effects of Beryllium Exposure: A Literature Review
TABLE 4-1 Genotoxicity Studies of Beryllium Compounds
Assay or End Point
Species
Compound
With Activation
Without Activation
Reference
In vitro
Plate incorporation assay
Salmonella typhimurium
BeSO4
Negative
Negative
Rosenkranz and Poirier 1979; Simmon 1979a; Simmon et al. 1979; Dunkel et al. 1984; Arlaukas et al. 1985; Ashby et al. 1990
S. typhimurium
Be(NO3 )2
Negative
Negative
Arlaukas et al. 1985; Kuroda et al. 1991
S. typhimurium
BeO
Negative
Negative
Kuroda et al. 1991
S. typhimurium
BeCl2
Negative
Negative
Kuroda et al. 1991
Eschericia coli WP-2 uvrA
BeSO4
Negative
Negative
Dunkel et al. 1984
Rec assay
Bacillus subtilis
BeSO4
—
Positive
Kada et al. 1980; Kanematsu et al. 1980
B. subtilis
BeCl2
—
Positive
Kuroda et al. 1991
B. subtilis
BeCl2
—
Negative
Nishioka 1975
B. subtilis
Be(N03 )2
—
Positive
Kuroda et al. 1991
B. subtilis
BeO
—
Negative
Kuroda et al. 1991
E. coli
BeSO4
—
Positive
Dylevoi 1990
DNA modification
E. coli pol A + /A −
BeSO4
—
Negative
Rosenkranz and Poirier 1979
Bioluminescence test
Photobacterium fischeri
BeCl2
—
Positive
Ulitzur and Barak 1988
Recombogenic activity
Saccharomyces cerevisiae
BeSO4
Negative
Negative
Simmon 1979b
Host-mediated assay
S. cerevisiae
BeSO4
—
Negative
Simmon et al. 1979
S. typhimurium
BeSO4
—
Negative
Simmon et al. 1979
Chromosomal aberration
Swine lymphocytes
BeCl2
—
Positive
Vegni-Talluri and Guiggiani 1967
Syrian hamster embryo cells
BeSO4
—
Positive
Larramendy et al. 1981
Human lymphocytes
BeSO4
—
Positive
Larramendy et al. 1981
Chinese hamster ovary cells
BeSO4
—
Negative
Brooks et al. 1989
Cytogenetic assay
Chinese hamster lung cells
BeSO4
Negative
Negative
Ashby et al. 1990
Sister chromatid exchange assay
Chinese hamster V79 cells
BeCl2
—
Positive
Kuroda et al. 1991
Chinese hamster V79 cells
Be(NO3 )2
—
Positive
Kuroda et al. 1991
Chinese hamster V79 cells
BeO
—
Negative
Kuroda et al. 1991
Syrian hamster embryo cells
BeSO4
—
Positive
Larramendy et al. 1981
Human lymphocytes
BeSO4
—
Positive
Larramendy et al. 1981
Human lymphocytes
BeSO4
—
Negative
Andersen 1983
Mouse macrophage P388D1 cells
BeSO4
—
Negative
Andersen 1983
DNA repair
Rat hepatocytes
BeSO4
—
Negative
Williams et al. 1982, 1989
