TABLE 4-1 Genotoxicity Studies of Beryllium Compounds

Assay or End Point

Species

Compound

With Activation

Without Activation

Reference

In vitro

Plate incorporation assay

Salmonella typhimurium

BeSO4

Negative

Negative

Rosenkranz and Poirier 1979; Simmon 1979a; Simmon et al. 1979; Dunkel et al. 1984; Arlaukas et al. 1985; Ashby et al. 1990

S. typhimurium

Be(NO3)2

Negative

Negative

Arlaukas et al. 1985; Kuroda et al. 1991

S. typhimurium

BeO

Negative

Negative

Kuroda et al. 1991

S. typhimurium

BeCl2

Negative

Negative

Kuroda et al. 1991

Eschericia coli WP-2 uvrA

BeSO4

Negative

Negative

Dunkel et al. 1984

Rec assay

Bacillus subtilis

BeSO4

Positive

Kada et al. 1980; Kanematsu et al. 1980

B. subtilis

BeCl2

Positive

Kuroda et al. 1991

B. subtilis

BeCl2

Negative

Nishioka 1975

B. subtilis

Be(N03)2

Positive

Kuroda et al. 1991

B. subtilis

BeO

Negative

Kuroda et al. 1991

E. coli

BeSO4

Positive

Dylevoi 1990

DNA modification

E. coli pol A+/A

BeSO4

Negative

Rosenkranz and Poirier 1979

Bioluminescence test

Photobacterium fischeri

BeCl2

Positive

Ulitzur and Barak 1988

Recombogenic activity

Saccharomyces cerevisiae

BeSO4

Negative

Negative

Simmon 1979b

Host-mediated assay

S. cerevisiae

BeSO4

Negative

Simmon et al. 1979

S. typhimurium

BeSO4

Negative

Simmon et al. 1979

Chromosomal aberration

Swine lymphocytes

BeCl2

Positive

Vegni-Talluri and Guiggiani 1967

Syrian hamster embryo cells

BeSO4

Positive

Larramendy et al. 1981

Human lymphocytes

BeSO4

Positive

Larramendy et al. 1981

Chinese hamster ovary cells

BeSO4

Negative

Brooks et al. 1989

Cytogenetic assay

Chinese hamster lung cells

BeSO4

Negative

Negative

Ashby et al. 1990

Sister chromatid exchange assay

Chinese hamster V79 cells

BeCl2

Positive

Kuroda et al. 1991

Chinese hamster V79 cells

Be(NO3)2

Positive

Kuroda et al. 1991

Chinese hamster V79 cells

BeO

Negative

Kuroda et al. 1991

Syrian hamster embryo cells

BeSO4

Positive

Larramendy et al. 1981

Human lymphocytes

BeSO4

Positive

Larramendy et al. 1981

Human lymphocytes

BeSO4

Negative

Andersen 1983

Mouse macrophage P388D1 cells

BeSO4

Negative

Andersen 1983

DNA repair

Rat hepatocytes

BeSO4

Negative

Williams et al. 1982, 1989



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