Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6

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Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 (2008)
Board on Environmental Studies and Toxicology (BEST)

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. "3 Aniline." Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6. Washington, DC: The National Academies Press, 2008.

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Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 6

Classification

10 min

30 min

1 h

4 h

8 h

End Point (Reference)

AEGL-3 (lethal)

120 ppm

(456 mg/m³)

40 ppm

(152 mg/m³)

20 ppm

(76 mg/m³)

5.0 ppm

(19 mg/m³)

2.5 ppm

(9.5 mg/m³)

>70% methemoglobin: lethality (extrapolated from data of Kim and Carlson 1986)

^aCutaneous absorption of the neat material may occur, adding to the systemic toxicity.

^bThe aromatic, amine-like odor of aniline will be noticeable by most individuals at these concentrations.

REFERENCES

E.I. du Pont de Nemours. 1982a. Inhalation median lethal concentration (LC₅₀). OTS 84003A, Docket 878220239. E.I. du Pont de Nemours and Co., Inc., Wilmington, DE.

Kakkar, P., S. Awasthi, and P. N. Viswanathan. 1992. Oxidative changes in brain of aniline-exposed rats. Arch. Environ. Contam. Toxicol. 23(3):307-309.

Kiese, M. 1974. Methemoglobinemia: A Comp rehensive Treatise. Cleveland, OH: CRC Press.

Kim, Y.C., and G.P. Carlson. 1986. The effect of an unusual workshift on chemical toxicity. II. Studies on the exposure of rats to aniline. Fundam. Appl. Toxicol. 7(1):144-152.

NRC (National Research Council). 1993. Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances. Washington, DC: National Academy Press.

NRC (National Research Council). 2000. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 1. Washington, DC: National Academy Press.

Pauluhn, J. 2002. Aniline-induced methemoglobinemia in dogs: Pitfalls of route-to-route extrapolations. Inhal. Toxicol. 14(9):959-973.

Seger, D.L. 1992. Methemoglobin-forming chemicals. Pp. 800-806 in Hazardous Materials Toxicology: Clinical Principles of Environmental Health, J.B. Sullivan, and G.R. Krieger, eds. Baltimore, MD: Williams & Wilkins.