10 min

30 min

1 h

4 h

8 h

End Point (Reference)

AEGL-3 (lethal)

120 ppm

(456 mg/m3)

40 ppm

(152 mg/m3)

20 ppm

(76 mg/m3)

5.0 ppm

(19 mg/m3)

2.5 ppm

(9.5 mg/m3)

>70% methemoglobin: lethality (extrapolated from data of Kim and Carlson 1986)

aCutaneous absorption of the neat material may occur, adding to the systemic toxicity.

bThe aromatic, amine-like odor of aniline will be noticeable by most individuals at these concentrations.


E.I. du Pont de Nemours. 1982a. Inhalation median lethal concentration (LC50). OTS 84003A, Docket 878220239. E.I. du Pont de Nemours and Co., Inc., Wilmington, DE.

Kakkar, P., S. Awasthi, and P. N. Viswanathan. 1992. Oxidative changes in brain of aniline-exposed rats. Arch. Environ. Contam. Toxicol. 23(3):307-309.

Kiese, M. 1974. Methemoglobinemia: A Comp rehensive Treatise. Cleveland, OH: CRC Press.

Kim, Y.C., and G.P. Carlson. 1986. The effect of an unusual workshift on chemical toxicity. II. Studies on the exposure of rats to aniline. Fundam. Appl. Toxicol. 7(1):144-152.

NRC (National Research Council). 1993. Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances. Washington, DC: National Academy Press.

NRC (National Research Council). 2000. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 1. Washington, DC: National Academy Press.

Pauluhn, J. 2002. Aniline-induced methemoglobinemia in dogs: Pitfalls of route-to-route extrapolations. Inhal. Toxicol. 14(9):959-973.

Seger, D.L. 1992. Methemoglobin-forming chemicals. Pp. 800-806 in Hazardous Materials Toxicology: Clinical Principles of Environmental Health, J.B. Sullivan, and G.R. Krieger, eds. Baltimore, MD: Williams & Wilkins.

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