. "5 Crotonaldehyde, trans and cis trans." Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6. Washington, DC: The National Academies Press, 2008.
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Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 6
10-min
30-min
1-h
4-h
8-h
44 ppm
27 ppm
14 ppm
2.6 ppm
1.5 ppm
Exposure route/Concentrations/Durations: Inhalation: see below for exposure times and concentrations.
Effects: Most deaths occurred by 4 days after exposure, and the animals had clear or slightly blood-tinged nasal exudate (rats that died within 1 day also had terminal convulsions); some had pulmonary congestion.
5-min ppm–mortality
10-min ppm–mortality
15-min ppm–mortality
30-min ppm–mortality
60 min ppm–mortality
240-min ppm–mortality
1,920 – 0/5
800 – 1/12
550 – 0/10
370 – 0/10
370 – 4/10
50 – 1/10
2,420 – 1/5
1,110 – 4/12
680 – 2/10
420 – 2/10
400 – 6/10
60 – 2/10
2,680 – 1/5
1,380 – 6/12
750 – 5/10
530 – 4/10
490 – 7/10
70 – 4/10
3,180 – 3/5
1,820 – 7/12
850 – 7/10
675 – 6/10
590 – 7/10
100 – 6/10
4,160 – 4/5
2,050 – 9/12
980 – 7/10
800 – 8/10
640 – 10/10
120 – 8/10
4,640 – 5/5
LC50 = 1480
1,090 – 8/10
890 – 9/10
LC50 = 391
200 – 9/10
LC50 = 3132
LC01 = 440
1,290 – 10/10
LC50 = 593
LC01 = 138
LC50 = 88
LC01 = 1492
LC50 = 809
LC01 = 268
LC01 = 26
LC01 = 419
End point/Concentration/Rationale: LC01 values, representing the NOEL for lethality, were obtained by probit analysis and used to obtain the 10-, 30-, 1-h, and 4-h AEGL-3 values. The 8-h values were derived from the 4-h LC01 by exponential time scaling and using n = 1.2.
Uncertainty factors/Rationale: Total uncertainty factor: 10
Interspecies: 3: Interspecies variability was small (LC50 values for rats, mice, and guinea pigs were within a factor of 2.5, and these studies yielded similar or higher AEGL-3 values).
Intraspecies: 3: Great human variability in unlikely given the homogeneity of the animal data, and a larger uncertainty factor yields 8-h AEGL-3 concentrations that caused only mild irritation in workers exposed for up to 8 h (Fannick 1982).
Modifying factor: None.
Animal to human dosimetric adjustment: Not applied
Time scaling: Performed only for 8-h time point by exponential scaling; i.e., Cn × t = k, where n = 1.2 was derived by ten Berge et al. (1986) from the Rinehart (1967) rat LC50 data.
Data adequacy: Database quality was considered adequate, and the key study was well conducted: 30-60 animals were tested per exposure time at five to seven crotonaldehyde concentrations, and a clear dose-response was obtained. Similar or higher AEGL-3 values could be obtained with mice, rats, and guinea pigs.
