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Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 6
TABLE 6-1 Summary of AEGL Values for 1,1- and 1,2-Dimethylhydrazines
End Point (Reference)
Not recommended due to insufficient data; concentration-response relationships suggest little margin between exposures causing minor effects and those resulting in serious toxicity.a
Behavioral changes and muscle fasciculations in dogs exposed to 360 ppm for 15 min (Weeks et al. 1963).
Lethality threshold of 327 ppm for 1 h estimated from 1-h LC50 in dogs (Weeks et al. 1963).
aRefer to AEGL-1 for hydrazine if hydrazine is also present. NR: not recommended. Numerical values for AEGL-1 are not recommended (1) because of the lack of available data, (2) because an inadequate margin of safety exists between the derived AEGL-1 and the AEGL-2, or (3) because the derived AEGL-1 is greater than the AEGL-2. Absence of an AEGL-1 does not imply that exposure below the AEGL-2 is without adverse effects.
NRC (National Research Council). 2000. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Vol. 1. Washington, DC: National Academy Press.
Weeks, M.H., G.C. Maxey, M.E. Sicks, and E.A. Greene. 1963. Vapor toxicity of UDMH in rats and dogs from short exposures. Am. Ind. Hyg. Assoc. J. 24:137-143.