TABLE 6-1 Summary of AEGL Values for 1,1- and 1,2-Dimethylhydrazines

Classification

10 min

30 min

1 h

4 h

8 h

End Point (Reference)

AEGL-1 (nondisabling)

NR

NR

NR

NR

NR

Not recommended due to insufficient data; concentration-response relationships suggest little margin between exposures causing minor effects and those resulting in serious toxicity.a

AEGL-2 (disabling)

18 ppm

(44 mg/m3)

6 ppm

(14.7 mg/m3)

3 ppm

(7.4 mg/m3)

0.75 ppm

(2 mg/m3)

0.38 ppm

(1 mg/m3)

Behavioral changes and muscle fasciculations in dogs exposed to 360 ppm for 15 min (Weeks et al. 1963).

AEGL-3 (lethal)

65 ppm

(159 mg/m3)

22 ppm

(54 mg/m3)

11 ppm

(27 mg/m3)

2.7 ppm

(6.6 mg/m3)

1.4 ppm

(3.4 mg/m3)

Lethality threshold of 327 ppm for 1 h estimated from 1-h LC50 in dogs (Weeks et al. 1963).

aRefer to AEGL-1 for hydrazine if hydrazine is also present. NR: not recommended. Numerical values for AEGL-1 are not recommended (1) because of the lack of available data, (2) because an inadequate margin of safety exists between the derived AEGL-1 and the AEGL-2, or (3) because the derived AEGL-1 is greater than the AEGL-2. Absence of an AEGL-1 does not imply that exposure below the AEGL-2 is without adverse effects.

REFERENCES

NRC (National Research Council). 2000. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Vol. 1. Washington, DC: National Academy Press.

Weeks, M.H., G.C. Maxey, M.E. Sicks, and E.A. Greene. 1963. Vapor toxicity of UDMH in rats and dogs from short exposures. Am. Ind. Hyg. Assoc. J. 24:137-143.



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