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Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 6
TABLE 6-1 Summary of AEGL Values for 1,1- and 1,2-Dimethylhydrazines
Classification
10 min
30 min
1 h
4 h
8 h
End Point (Reference)
AEGL-1 (nondisabling)
NR
NR
NR
NR
NR
Not recommended due to insufficient data; concentration-response relationships suggest little margin between exposures causing minor effects and those resulting in serious toxicity.a
AEGL-2 (disabling)
18 ppm
(44 mg/m3)
6 ppm
(14.7 mg/m3)
3 ppm
(7.4 mg/m3)
0.75 ppm
(2 mg/m3)
0.38 ppm
(1 mg/m3)
Behavioral changes and muscle fasciculations in dogs exposed to 360 ppm for 15 min (Weeks et al. 1963).
AEGL-3 (lethal)
65 ppm
(159 mg/m3)
22 ppm
(54 mg/m3)
11 ppm
(27 mg/m3)
2.7 ppm
(6.6 mg/m3)
1.4 ppm
(3.4 mg/m3)
Lethality threshold of 327 ppm for 1 h estimated from 1-h LC50 in dogs (Weeks et al. 1963).
aRefer to AEGL-1 for hydrazine if hydrazine is also present. NR: not recommended. Numerical values for AEGL-1 are not recommended (1) because of the lack of available data, (2) because an inadequate margin of safety exists between the derived AEGL-1 and the AEGL-2, or (3) because the derived AEGL-1 is greater than the AEGL-2. Absence of an AEGL-1 does not imply that exposure below the AEGL-2 is without adverse effects.
REFERENCES
NRC (National Research Council). 2000. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Vol. 1. Washington, DC: National Academy Press.
Weeks, M.H., G.C. Maxey, M.E. Sicks, and E.A. Greene. 1963. Vapor toxicity of UDMH in rats and dogs from short exposures. Am. Ind. Hyg. Assoc. J. 24:137-143.
