STATEMENT OF TASK

Members of the committee were selected for their expertise in inhalation toxicology, neurotoxicology, immunotoxicology, reproductive and developmental toxicology, veterinary pathology, pharmacokinetics, epidemiology, and human-health risk assessment. The committee was specifically asked to accomplish the following tasks:

  • Evaluate the Navy's current and proposed 1-h and 24-h EEGLs and 90-day CEGLs for the following substances: 2190 oil mist, formaldehyde, acrolein, ozone, monoethanolamine, nitric oxide, nitrogen dioxide, oxygen, carbon dioxide, carbon monoxide, methanol, ammonia, benzene, hydrazine, Freon 12, Freon 114, hydrogen, toluene, and xylene.

  • Determine whether the current or proposed guidance levels are consistent with the scientific data and whether the Navy's exposure levels should be changed on the basis of the committee's evaluation.

  • For two submarine contaminants for which no guidance levels exist—surface lead and 2,6-di-tert-butyl-4-nitrophenol (DBNP)—determine whether sufficient data are available to develop EEGLs and CEGLs and, if so, provide recommendations for guidance levels consistent with the data.

  • Identify deficiencies in the database relevant to EEGL and CEGL development for the selected chemical substances, and make recommendations for future research when appropriate.

To accomplish its review, the committee was asked to use the Navy's supporting documentation and other relevant toxicologic and epidemiologic data and publish the results of its evaluations in two reports. This is the committee's second report. It contains the EEGL and CEGL recommendations for the following chemicals of concern to the Navy: ammonia, benzene, DBNP, Freon 12, Freon 114, hydrogen, 2190 oil mist, ozone, surface lead, toluene, and xylene. All other chemicals were addressed in the committee’s first report.

APPROACH TO STUDY

In conducting its evaluations, the committee reviewed relevant human and animal data and used data-selection criteria described in the NRC report Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals.1 Where possible, primary references were used to derive

1

National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: National Academy Press.



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