Following completion of several large ongoing studies, a “weight-of-the-evidence” analysis can be conducted to synthesize and evaluate the entire data set. At that time, rational, informed decisions can be made concerning the value of conducting additional oncogenicity2 studies in standard-bred laboratory animals.
The use of genetically engineered animals may increase the sensitivity of laboratory studies to detect weak effects, and may be particularly suitable to evaluate the possible interactions between RF fields and other agents in disease causation.
The overall database for RF fields and cancer would be strengthened by additional studies using multi-stage model systems for cancer in tissues (such as the brain) that have been hypothesized to be targets of RF action.
Although genetic toxicology studies have failed to identify potential RF health effects, additional genetic toxicology studies may be warranted should evidence of oncogenicity be identified in any of the ongoing chronic toxicity/oncogenicity bioassays of RF fields in laboratory animals, or in any future studies to be performed using genetically engineered animal models.
A number of potentially critical cancer-related endpoints have received only very limited study and are identified in the report text.
In addition to cancer-related endpoints, data gaps exist in a number of other areas of toxicology in which knowledge is needed to support a complete evaluation of the possible health effects of RF exposure; these gaps are identified in the body of the report.