analysis is necessary to fully elucidate cellular responses to toxic injury, particularly those mediated by direct modification of proteins and/or disruption of metabolic networks involved in tissue homeostasis.

  1. Examine the sensitivity of current toxicogenomic-based methodologies and analyses and their ability to distinguish between endogenous and exogenous effects at biologically relevant doses.

  2. Implement educational programs to help the toxicology and risk assessment communities incorporate toxicogenomic approaches and data-rich mechanistic assessments into their professional practice.

Long-Term Actions

  1. When appropriate, encourage a shift in the focus of mechanistic investigations from single genes to more integrated analyses that embrace the complexity of biologic systems as a whole as well as the multidimensionality of dose- and time-related effects of toxic agents.

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