open to the research community. Specific tools that are needed include the following:

  1. Algorithms that facilitate accurate identification of orthologous genes and proteins in species used in toxicologic research,

  2. Tools to integrate data across multiple analytical platforms (for example, gene sequences, transcriptomics, proteomics, and metabolomics), and

  3. Computational models to enable the study of network responses and systems-level analyses of toxic responses.

  1. Continue to improve genome annotation for all relevant species and elucidation of orthologous genes and pathways.

  2. Emphasize the development of standards to ensure data quality and to assist in validation.

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