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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This study was supported by Grant No. 56822 between the National Academy of Sciences and the Robert Wood Johnson Foundation. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

Library of Congress Cataloging-in-Publication Data

Knowing what works in health care : a roadmap for the nation / Committee on Reviewing Evidence to Identify Highly Effective Clinical Services, Board on Health Care Services ; Jill Eden … [et al.], editors.

p. ; cm.

Includes bibliographical references.

ISBN 978-0-309-11356-4 (hardcover)

1. Medical care--Standards—United States. 2. Medical care—United States—Quality control. 3. Evidence-based medicine—United States. I. Eden, Jill. II. Institute of Medicine (U.S.). Committee on Reviewing Evidence to Identify Highly Effective Clinical Services.

[DNLM: 1. Quality Assurance, Health Care—standards—United States. 2. Evidence-Based Medicine—standards—United States. 3. Organizational Innovation—United States. 4. Practice Guidelines as Topic—standards—United States. W 84 AA1 K73 2008]

RA399.A3K56 2008



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The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of Medicine is a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.

Suggested citation: Institute of Medicine (IOM). 2008. Knowing what works in health care: A roadmap for the nation. Washington, DC: The National Academies Press.

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