Jim will long be remembered for his important contributions to a wide range of biological and neuroscience areas. His work on the cerebellum, spinal cord, brainstem reticular formation, superior colliculus, and the multiple visual cortical areas and pathways will remain his legacy and seminal contribution to the field of neuroscience. Jim will also be remembered for his contributions to the University of Pennsylvania as one of the founders and as director of the Institute of Neurological Sciences (1973-1980). He also served as chair of the Department of Anatomy (now the Department of Cell and Molecular Biology) from 1968 to 1975.

Both authors of this memoir were students and later colleagues of Jim Sprague and both of us greatly lament his loss of a role model, mentor, and close personal friend. He will be missed but never forgotten by us, or by the hundreds of younger neuroscientists who will continue to amplify and extend the discoveries that are his legacy.