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DR. JENSEN: I am interested in the motif-finding aspect. Usually, with these algorithms you find all frequently occurring patterns, and then at some point you go on threshold. You say, you know things about the threshold, those are unexpected things, but because of the nature of them it is often difficult to do good hypotheses tests and say where we should draw that threshold. So, what approach did you use for saying these are motifs that seem big and interesting?

DR. IYENGAR: Actually, I did not have a real initial statistical threshold, because I was going from a biological point of view. The protein that participated was known to have important biology.


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