National Academy of Sciences | 150 Year Anniversary

Questions? Call 800-624-6242

| Items in cart [0]

The National Academies Press

Rights & Permissions

topleft topright

New Vaccine Development: Establishing Priorities: Volume I, Diseases of Importance in the United States (1985)
Board on Population Health and Public Health Practice (BPH)

Citation Manager

. "7. Calculation and Comparison of the Health Benefits and Costs Associated with Candidate Vaccines." New Vaccine Development: Establishing Priorities: Volume I, Diseases of Importance in the United States. Washington, DC: The National Academies Press, 1985.

Please select a format:

BibTeX EndNote RefMan


Page
115
bottomleft bottomright

The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy.


New Vaccine Development Establishing Priorities, Volume I: Diseases of Importance in the United States

Herpesvirus varicellae

Attenuated live virus

Recipients of bone narrow and organ transplants and persons under age 25 with leukemias and lymphomas

558

337

320

237

372

231

219

162

 

 

Normal susceptibles, routine for children (booster for adults)

1391

1112

445

167

960

746

298

112

Influenza viruses A & B

Subunit vaccine (purified hemagglutinin/ neuramindase proteins)

High-risk population as currently defined (see Appendix K)

10644

9048

814

521

28225

23991

2159

1381

 

Attenuated live virus

High-risk population as currently defined

10644

9048

1357

504

28225

23991

3599

1336

Neisseria gonorrhoeae

A small number of promising options need investigation to determine best approach

Adolescents and adults age 15 and over

527

444

44

8

13811

(347)

11738

(294)

1174

(29.4)

201

(5)

Parainfluenza viruses

Trivalent, subunit vaccine (must contain fusion protein)

Infants

660

561

297

132

584

496

263

117

Respiratory Syncytial virus

Glycoprotein produced by recombinant DNA technology

Infants

3827

3062

980

458

3775

3020

966

452

 

Attenuated live virus

Infants

3827

3062

1623

759

3775

3020

1601

749

Rotavirus

Attenuated live bovine virus

Infants

281

253

68

41

227

204

55

33

 

Attenuated live human or reassortment virus

Infants

281

253

68

38

227

204

55

30

Streptococcus group B

Conjugated polysaccharide

Pregnant women for fetuses and neonates

3570

2856

314

125

3528

2823

311

124

aSee text and appendixes for explanation and derivation.

bAdjusted for vaccine efficacy; see text for explanation where efficacy varies with conditions.

cAdjusted for anticipated utilization.

dAdjusted for probability of success and time at which steady state of benefits would be achieved.

Page
115
Front Matter (R1-R14)
1. Summary (1-16)
2. Priority Setting for Health Related Investments: A Review of Methods (17-27)
3. Overview of the Analytic Approach (28-38)
4. Comparison of Disease Burdens and Costs (39-58)
5. Predictions on Vaccine Development (59-66)
6. Assessing the Likely Utilization of New Vaccines (67-91)
7. Calculation and Comparison of the Health Benefits and Costs Associated with Candidate Vaccines (92-120)
8. Additional Issues in the Selection of Priorities for Accelerated Vaccine Development (121-126)
9. Findings, Conclusions, and Recommendations (127-148)
Appendix A: Some Examples of the Application of Project Selection Method (149-152)
Appendix B: Pathogenic Agents for Which Accelerated Vaccine Development Does Not Appear Appropriate (153-170)
Appendix C: Prospects for Immunizing Against Bordetella pertussis (171-182)
Appendix D: Prospects for Immunizing Against Coccidioidomycosis (183-197)
Appendix E: Prospects for Immunizing Against Cytomegalovirus (198-234)
Appendix F: Prospects for Immunizing Against Hemophilus influenzae type b (235-251)
Appendix G: Prospects for Immunizing Against Hepatitis A Virus (252-260)
Appendix H: Prospects for Immunizing Against Hepatitis B Virus (261-279)
Appendix I: Prospects for Immunizing Against Herpes Simplex Viruses 1 and 2 (280-312)
Appendix J: Prospects for Immunizing Against Herpesvirus varicellae (313-341)
Appendix K: Prospects for Immunizing Against Influenza Viruses A and B (342-364)
Appendix L: Prospects for Immunizing Against Neisseria gonorrhoeae (365-384)
Appendix M: Prospects for Immunizing Against Parainfluenza Viruses (385-396)
Appendix N: Prospects for Immunizing Against Respiratory Syncytial Virus (397-409)
Appendix O: Prospects for Immunizing Against Rotavirus (410-423)
Appendix P: Prospects for Immunizing Against Streptococcus group B (424-439)
Appendix Q: Questionnaire for Assessing Morbidity-Mortality Trade-Offs (440-443)
Appendix R: Technical Notes (444-444)
Appendix S: Biographical Notes on Committee Members (445-449)
Appendix T: Additional Sources of Advice to the Committee (450-452)
Index (453-458)