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TABLE J.13 Estimated Morbidity and Mortality Due to Varicella-Zoster (VZV) Infections in Recipients of Cardiac and Liver Transplants

 

Age (years)

 

Under 1

1–4

5–14

15–24

25–59

60 and Over

Number of liver transplantsa

 

9

21

25

121

 

Number of cardiac transplantsa

 

 

 

 

100

 

Number with clinically apparent VZV infection (35% of transplants)b

 

3

7

9

77

 

Number with disseminated VZV disease (20% of clinically apparent VZV infections)c

 

1

1

2

15

 

Fatalities (7% of clinically apparent VZV infections)

 

1

1

1

5

 

aNumber of transplants estimated by Scharschmidt (personal communication, 1984). Age distribution derived from estimates provided by Scharschmidt (personal communication, 1984) and from distribution of projected 1984 U.S. population (Bureau of the Census, 1984); all cardiac transplants assumed to occur in the 25–59 years age group.

bRisk of infection and death assumed same as for patients with lymphomas and leukemias see Table J.11).

cRisk of dissemination assumed slightly higher than for recipients of renal transplants because of more intense immunosuppressive therapy.

TABLE J.14 Estimated Morbidity and Mortality Associated with Varicella-Zoster (V2V) infections in Recipients of Allogeneic Bone Marrow Transplants

 

Age (years)

 

Under 1

1–4

5–14

15–24

25–59

60 and Over

Number of Transplantsa,b

30

118

490

601

536

74

Number with clinically apparent VZV infection (65% of transplants)c

20

77

319

391

348

48

Number with disseminated disease (30% of clinically apparent VZV infections)d

6

23

96

117

104

14

Fatalities (8% of clinically apparent VZV infections)e

2

6

26

31

28

4

aNumber of transplants assumed to equal number of transplant recipients. Data on the number of transplants were obtained from the Statistical Center of the International Bone Marrow Transplant Registry (1983). These data have not been reviewed or approved by the Advisory Committee of the IBMTR. Figures have been projected for 1984 at an estimated increase of 52 percent.

bAge distribution derived from data reported in Meyers et al. (1982).

cFrom data cited in Weller (1983b).

dAverages of percentages reported in Feldman et al. (1975) and Reboul et al. (1978).

eFrom data cited in Weller (1983b).



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