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The Development of DRIs 1994–2004: Lessons Learned and New Challenges - Workshop Summary
Appendix A
Workshop Agenda and Background Materials
AGENDA
Institute of Medicine, Food and Nutrition Board Workshop
The Development of DRIs 1994–2004: Lessons Learned and New Challenges
The NAS Auditorium
2100 C Street, NW
Washington, DC
September 18–20, 2007
***** DAY 1 – September 18 *****
7:30–8:30 am
Registration
INTRODUCTION
8:30–9:00
Welcome and Opening Remarks
John Suttie, Chair, University of Wisconsin
9:00–9:30
Overview of Current DRI Framework and Issues Raised
Christine Taylor, Institute of Medicine
9:30–10:00
Break
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SESSION 1
CONCEPTUAL FRAMEWORK FOR DRI DEVELOPMENT
Moderator: Stephanie Atkinson, McMaster University
10:00–10:40
Current Framework for DRI Development: What Are the Pros and Cons?
Robert M. Russell, Tufts University
10:40–10:55
Case Study: Applying the DRI Framework to Chronic Disease Endpoints
Paula Trumbo, Center for Food Safety and Applied Nutrition, FDA
10:55–11:10
Case Study: Applying the DRI Framework to Non-Chronic Disease Endpoints
Allison Yates, Agricultural Research Service, USDA
11:10–11:50
Discussion: Framework Pros/Cons; Case Studies
Co-Discussants: Patsy Brannon, Cornell University, and Alice H. Lichtenstein, Tufts University
11:10–11:30
Discussion among co-discussants/presenters
11:30–11:50
Discussion open to all attendees
11:50 am–12:20 pm
Two Perspectives: The DRI Framework
Perspective I: George Beaton, University of Toronto
Perspective II: Janet King, University of California, Berkeley and Davis
12:20–12:30
Question and Answer Session on Perspectives
12:30–1:30
Lunch
1:30–1:45
Evaluating Evidence for DRI Development: What Are the Issues in Applying Systematic Evidence-Based Review Approaches to DRI Development?
Alice H. Lichtenstein, Tufts University
1:45–2:15
Risk Assessment: Is It a Relevant Organizing Structure?
Elizabeth A. Yetley, Office of Dietary Supplements, NIH
2:15–2:55
Discussion: Systematic Evidence-Based Review; Risk Assessment
Discussant: Sanford Miller, University of Maryland
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2:15–2:35
Discussion among discussant/presenters
2:35–2:55
Discussion open to all attendees
2:55–3:15
Break
3:15–5:15
Panel Discussion: In What Ways Could the Conceptual Framework Be Enhanced?
Panel Members: Cutberto Garza, Boston College; Mary L’Abbé, Health Canada; Irwin Rosenberg, Tufts University; and Barbara Stoecker, Oklahoma State University
3:15–3:35
Opening remarks from panel members
3:35–4:00
Cross-panel discussion
4:00–5:15
Discussion open to all attendees
***** DAY 2 – September 19 *****
SESSION 2
CRITERIA FOR SCIENTIFIC DECISION MAKING
Moderator: Robert M. Russell, Tufts University
8:30–8:50 am
Selecting Endpoints: What Are the Issues and What Are the Options for Criteria?
Irwin Rosenberg, Tufts University
8:50–9:00
Discussion
9:00–9:15
Dose–Response Data: Are There Options for Dealing with Limited Data?
Susan Taylor Mayne, Yale School of Public Health
9:15–9:30
Discussion
9:30–9:45
What Are the Challenges in Addressing Extrapolation/ Interpolation for Unstudied Groups?
Stephanie A. Atkinson, McMaster University
9:45–10:00
Discussion
10:00–10:30
Break
10:30–10:45
What Are the Challenges in Addressing Adjustment for Data Uncertainty?
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Hildegard Przyrembel, Federal Institute for Risk Assessment, Berlin, Germany
10:45–11:00
Discussion
11:00–11:20
Estimating Dietary Intake: What Are the Implications for DRI Development?
Amy Subar, National Cancer Institute, NIH
11:20–11:30
Discussion
11:30–11:45
Highlights of Other Important Issues: Physiological, Genomic, and Environmental Factors
Cutberto Garza, Boston College
11:45 am–12:00 pm
Discussion
12:00–1:00
Lunch
SESSION 3
GENERAL GUIDANCE FOR USERS OF DRIs
Moderator: Mary Bush, Health Canada
1:00–1:20 pm
Overview: Issues Raised About General Guidance for Users
Christine Taylor, Food and Nutrition Board, Institute of Medicine
1:20–1:40
Discussion
Discussant: Johanna Dwyer, Office of Dietary Supplements, NIH
1:20–1:30
Discussion between discussant/presenter
1:30–1:40
Discussion open to all attendees
1:40–2:05
Special Challenges: Planning and Assessing the Total Diet—What Are the Issues and What Are the Options for Enhanced Guidance?
Suzanne Murphy, University of Hawaii
Susan Barr, University of British Columbia
2:05–2:30
Discussion
Co-Discussants: Patricia Guenther, Center for Nutrition
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Policy and Promotion, USDA, and Krista Esslinger, Health Canada
2:05–2:20
Discussion among co-discussants/presenters
2:20–2:30
Discussion open to all attendees
2:30–2:45
Break
2:45–3:10
Special Challenges: What Are the Issues Related to a Framework for Individual-Level and Group-Level Applications?
Valerie Tarasuk, University of Toronto
3:10–3:30
Discussion
Discussant: Gerard Dallal, Tufts University
3:10–3:20
Discussion between discussant/presenter
3:20–3:30
Discussion open to all attendees
3:30–5:15
Panel Discussion: In What Ways Could the Guidance for Users of DRIs Be Enhanced?
Panel Members: Danielle Brulé, Health Canada; Mary Frances Picciano, Office of Dietary Supplements, NIH; William Rand, Tufts University School of Medicine; and Linda Van Horn, Northwestern University
3:30–3:50
Opening remarks from panel members
3:50–4:15
Cross-panel discussion
4:15–5:15
Discussion open to all attendees
***** DAY 3 – September 20 *****
SESSION 4
LOOKING TO THE FUTURE PROCESS FOR DRI DEVELOPMENT
Moderator: Paul Coates, Office of Dietary Supplements, NIH
8:30–8:45 am
Emerging Issues: What New Challenges Might the Future Hold?
Catherine Woteki, Mars, Inc.
8:45–8:55
Discussion
8:55–9:10
Is There a Need to Enhance Transparency of the Decision-Making Process?
Robert M. Russell, Tufts University
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9:10–9:20
Discussion
9:20–9:35
IOM Overview of Options for Stakeholder Input
Linda D. Meyers, Food and Nutrition Board, Institute of Medicine
9:35–9:45
Discussion
9:45–10:00
What Are the Criteria Options for Determining When to Update/Review Existing DRIs?
John Suttie, Chair, University of Wisconsin
10:00–10:10
Discussion
10:10–10:25
What Are the Considerations in Specifying “New” Nutrient Substances for DRI Study?
Peter Greenwald, National Cancer Institute, NIH
10:25–10:35
Discussion
10:35–10:50
Break
10:50 am–12:45 pm
Panel Discussion: Reflections on What We Have Heard
About the Process of DRI Development
Panel Members: Mary Bush, Health Canada; Jean-Pierre Habicht, Cornell University; Suzanne Harris, ILSI Research Foundation; Van Hubbard, Division of Nutrition Research Coordination, NIH; and Molly Kretsch, Agricultural Research Service, USDA
10:50–11:15
Opening remarks from panel members
11:15–11:50
Cross-panel discussion
11:50–12:45
Discussion open to all attendees
12:45–1:15
Summary and Closing Remarks
Chair’s Summary (John Suttie)
Closing Remarks from Sponsor Representative (Paul Coates)
Chair’s Close of Workshop
WORKSHOP BACKGROUND MATERIALS
The following background materials were made available via the IOM website to the general public and workshop participants for viewing prior to
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the workshop. The documents and the comments received can be accessed at www.iom.edu/driworkshop2007.
IOM Publication: How Should the Recommended Dietary Allowances Be Revised? (1994)
Tables: Comparisons of Outcomes/Approaches Among DRI Nutrients
International Documents: Food and Agriculture Organization of the United Nations and the World Health Organization
Paper: Risk Assessment: Is It a Relevant Organizing Structure? (Yetley)
Paper: Selection of Endpoints for Determining EARs/AIs and ULs (Cheney)
Paper: DRI Development Process; Issues Related to Extrapolation and Interpolation for Unstudied Groups (Atkinson)
Paper: DRI Development Process; Issues Related to the Adjustment for Data Uncertainty (Przyrembel)
Paper: DRI Development Process; Issues of Variability (Rand)
Paper: Approximating Dose-Response in the Face of Limited Data (Mayne)
Paper: Uses and Challenges in Applying the DRIs; U.S. Federal DRI Steering Committee
Paper: Uses and Challenges in Applying the DRIs; Health Canada
Paper: Uses and Challenges in Applying the DRIs; American Dietetic Association
Paper: Uses and Challenges in Applying the DRIs; Dietitians of Canada
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