Appendix C



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Appendix C 

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Eight Americas: Investigating Mortality Disparities Across Races, Counties, and Race-Counties in the United States1 Christopher J. L. Murray, Sandeep C. Kulkarni, Catherine Michaud, Niels Tomijima, Maria T. Bulzacchelli, Terrell J. Iandiorio, Majid Ezzat Funding: This research was supported by a cooperative agreement, awarded by the Centers for Disease Control and Prevention and the Association of Schools of Public Health (grant U36/CCU300430–23) and by the National Institute on Aging (grant PO1AG17625). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the Association of Schools of Public Health. 1 Reprinted, with permission, from PLoS Medicine, http://medicine.plosjournals.org/perlserv/ ?SESSID=d0a2681557eece4143f1a664d5536f5f&request=get-document&doi=10.1371/journal. pmed.0030260. 2 Harvard School of Public Health, Harvard University Initiative for Global Health, and Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts. 3 Harvard University Initiative for Global Health, Cambridge, Massachusetts, and University of California San Francisco, San Francisco, California. 4 Harvard University Initiative for Global Health, and Center for Population and Develop- ment Studies, Harvard University, Cambridge, Massachusetts. 5 Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts. 6 Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts. 7 Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts. 

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 CHALLENGES AND SUCCESSES IN REDUCING HEALTH DISPARITIES Competing Interests: The authors have declared that no competing interests exist. Academic Editor: Thomas Novotny, University of California San Francisco. Citation: Murray CJL, Kulkarni SC, Michaud C, Tomijima N, Bulzacchelli MT, et al. (2006) Eight Americas: Investigating mortality disparities across races, counties, and race-counties in the United States. PLoS Med 3(9): e260. DOI: 10.1371/journal.pmed.0030260. Received: October 17, 2005 Accepted: March 31, 2006 Published: September 12, 2006 DOI: 10.1371/journal.pmed.0030260 Copyright: © 2006 Murray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abbreviations: BRFSS, Behavioral Risk Factor Surveillance System; NCHS, National Center for Health Statistics; SES, socioeconomic status. ABSTRACT Background The gap between the highest and lowest life expectancies for race- county combinations in the United States is over 35 y. We divided the race-county combinations of the US population into eight distinct groups, referred to as the ‘‘eight Americas,’’ to explore the causes of the disparities that can inform specific public health intervention policies and programs. Methods and Findings The eight Americas were defined based on race, location of the county of residence, population density, race-specific county-level per capita income, and cumulative homicide rate. Data sources for population and mortality figures were the Bureau of the Census and the National Center for Health Statistics. We estimated life expectancy, the risk of mortality from specific diseases, health insurance, and health-care utilization for

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 APPENDIX C the eight Americas. The life expectancy gap between the 3.4 million high- risk urban black males and the 5.6 million Asian females was 20.7 y in 2001. Within the sexes, the life expectancy gap between the best-off and the worst-off groups was 15.4 y for males (Asians versus high-risk urban blacks) and 12.8 y for females (Asians versus low-income southern rural blacks). Mortality disparities among the eight Americas were largest for young (15–44 y) and middle-aged (45–59 y) adults, especially for men. The disparities were caused primarily by a number of chronic diseases and injuries with well-established risk factors. Between 1982 and 2001, the ordering of life expectancy among the eight Americas and the absolute difference between the advantaged and disadvantaged groups remained largely unchanged. Self-reported health plan coverage was lowest for western Native Americans and low-income southern rural blacks. Crude self-reported health-care utilization, however, was slightly higher for the more disadvantaged populations. Conclusions Disparities in mortality across the eight Americas, each consisting of millions or tens of millions of Americans, are enormous by all international standards. The observed disparities in life expectancy cannot be explained by race, income, or basic health-care access and utilization alone. Because policies aimed at reducing fundamental socioeconomic inequalities are cur- rently practically absent in the US, health disparities will have to be at least partly addressed through public health strategies that reduce risk factors for chronic diseases and injuries. The Editors’ Summary of this article follows the references. INTRODUCTION Health disparities in the United States have been the subject of exten- sive critical scrutiny and analysis. Multiple investigations have documented the consistent gap in all measures of mortality by race, particularly between black and white Americans [1–5]. Researchers have also drawn attention to substantial disparities in mortality and functional health status nation- ally and within race groups in relation to income, social class, education, and community characteristics [6–16]. Inequalities in insurance coverage, health-care access and utilization, and more recently in quality of care have also been investigated [17–22]. The Department of Health and Human Services has launched its Initiative to Eliminate Racial and Ethnic Dispari- ties in Health, with programs focused on a number of diseases including cardiovascular disease, HIV, and diabetes. Life expectancy by race in the US in 2001 ranged from 86.7 for Asian

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 CHALLENGES AND SUCCESSES IN REDUCING HEALTH DISPARITIES females to 68.7 for black males, a gap of 18 y. Analysis of life expectancy by county of residence and by the combination of race and county of residence (referred to as ‘‘race-county’’ in this paper) demonstrates even larger disparities [23]. County-level analysis of mortality for 1997–2001 (pooled over 5 y to increase sample size) demonstrates a 22.5-y gap in life expectancy between males in southwest South Dakota and females in Stearns County, Minnesota (see Dataset S1 for life expectancy by county). When race-county combinations are considered, life expectancy disparities are dramatically larger. For example, Native American males in the cluster of Bennet, Jackson, Mellette, Shannon, Todd, and Washabaugh Counties in South Dakota had a life expectancy of 58 y in 1997–2001, compared to Asian females in Bergen County, New Jersey, with a life expectancy of 91 y, a gap of 33 y (see also Figure 1). Mortality inequalities in subgroups within race-counties, such as those defined based on socioeconomic status (SES), may be even larger. Because of small sample size and the absence of individual-level linked data needed to study race-county-SES combinations, it is currently not possible to study mortality patterns within race groups in small geographic areas, or even states. The largest measurable gaps observed in the US to-date are those revealed by examining the inequalities across race-county groups. Formulating effective policies and programs to ameliorate health inequalities requires an understanding of the interrelated causes of mortal- ity disparities, specific interventions to mitigate these causes, and interven- tion delivery mechanisms [24,25]. Efforts to characterize the contributions of specific diseases and injuries, risk factors such as tobacco, alcohol, or obesity, access to effective health care, and the broader socioeconomic determinants of health and disease are severely hampered by data limita- tions: the analysis of mortality by age and disease for specific race-counties is affected by the small numbers of deaths, such that even pooling data for 10 y or more does not provide sufficient person-years of observation to draw stable and robust conclusions for some diseases, especially by age. Data on risk factor exposure and health-care access and utilization are even more limited, as there are almost no sources of information on these variables by race and county. In order to investigate the causes of the observed race-county mortality disparities, within the limitations posed by sample size, we have divided US race-counties into eight subgroups based on a number of sociodemographic and geographical variables, referred to as the ‘‘eight Americas.’’ In addition to examining the role of specific diseases in age-specific and all-age mor- tality disparities, the eight Americas analysis identifies distinct subgroups, based on a small number of sociodemographic and geographical indicators, towards whom public health and medical interventions may be targeted. We

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 APPENDIX C emphasize that the grouping of US race-counties into the eight Americas in our analysis is not the only division that could be used for understanding the large mortality inequalities across racecounties. This grouping however reveals important variations in total as well as age-, sex-, and disease- specific mortality that call for further investigation of causes and potential interventions. METHODS Definition of the Eight Americas We estimated life expectancy for eight subgroups of the US population, which we refer to as the ‘‘eight Americas.’’ The building blocks for the eight Americas were a combination of race and county of residence. The race-county units were combined based on a number of socioeconomic and geographical indicators, including the location of the county of residence, population density, race-specific county-level per capita income, and cumu- lative homicide rate (Table 1; Figure 2). We arranged the 3,141 US counties into 2,072 individual or merged county units. There were two reasons for forming merged county units. (1) To avoid very small county populations and numbers of deaths, smaller counties were merged with adjacent counties to form units with total popu- lation of at least 10,000 males and 10,000 females. (2) Merged county units were also formed where necessary to account for changes in county status and county lines, such as formations of new counties and incorporation of independent cities (which are officially equivalent to counties) into surround- ing counties. The result was a consistent set of 2,072 individual or merged county units that represent the same physical land areas from 1980 through the present. We then divided the entire US population (the race-county units) into eight distinct subgroups, the eight Americas, based on the location of the county of residence, population density, per capita income of the county of residence in 1990, and cumulative homicide rate (averaged between 1991 and 2001 to reduce sensitivity to outlier years) (Table 1; Figure 2). We used 2 a population density of greater than 100 persons/km to distinguish urban from rural areas. Low-income race-county combinations were defined as those below the national median of race-specific county-level per capita income. Cumulative homicide rate was used as an indicator of deterioration of social institutions and neighborhood cohesion. These factors have been found to adversely affect health outcomes above and beyond individual characteristics [26,27]. High-risk urban areas were defined as those where the cumulative probability of homicide death between the ages of 15 and 74 exceeded the 95th percentile of all US counties, or 1.1%.

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Figure 1. County Life Expectancies by Race Deaths were averaged for 1997–2001 to reduce sensitivity to small numbers and outliers. (A) Life expectancy at birth for black males and females. Only counties with more than five deaths for any 5-y age group (0–85) were mapped, to avoid unstable results. C-1.eps (B) Life expectancy at birth for white males and females. broadside DOI: 10.1371/journal.pmed.0030260.g001 bitmap image 

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Table 1. Definitions and Basic Sociodemographic Characteristics of the Eight Americas  Average Percent Population Income Per Completing America General Description (Millions) Capita High School Definition 1 Asian 10.4 $21,566 80% Asians living in counties where Pacific Islanders make up less than 40% of total Asian population 2 Northland low- 3.6 $17,758 83% Whites in northern plains and Dakotas with 1990 county-level income rural white per capita income below $11,775 and population density less 2 than 100 persons/km 3 Middle America 214.0 $24,640 84% All other whites not included in Americas 2 and 4, Asians not in America 1, and Native Americans not in America 5 4 Low-income whites 16.6 $16,390 72% Whites in Appalachia and the Mississippi Valley with 1990 in Appalachia and the county-level per capita income below $11,775 Mississippi Valley 5 Western Native 1.0 $10,029 69% Native American populations in the mountain and plains areas, American predominantly on reservations 6 Black Middle 23.4 $15,412 75% All other black populations living in countries not included in America Americas 7 and 8 7 Southern low-income 5.8 $10,463 61% Blacks living in counties in the Mississippi Valley and the 2 rural black Deep South with population density below 100 persons/km , 1990 county-level per capita income below $7,500, and total population size above 1,000 persons (to avoid small numbers) 8 High-risk urban black 7.5 $14,800 72% Urban populations of more than 150,000 blacks living in counties with cumulative probability of homicide death between 15 and 74 y greater than 1.0% Population, income per capita, and education were calculated for race-county combinations from the 2000 US census. DOI: 10.1371/journal.pmed.0030260.t001

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 APPENDIX C Figure 2. Construction of the Eight Americas from 8,288 Race-County Units C-2.eps DOI: 10.1371/journal.pmed.0030260.g002 bitmap image Data Sources for Population, Mortality, and Sociodemographic Indicators Bureau of the Census population estimates and National Center for Health Statistics bridged-race population estimates. For 1982–1989, we interpolated age-, sex-, race-, and county-specific population figures using the 1980 and 1990 censual figures, assuming a constant growth rate. For 1990–2001, we used the bridged-race population estimates, released by the National Center for Health Statistics (NCHS), to be consistent with race categories used in mortality registration [28]. Race was defined according to the 1977 US Office of Management and Budget definition of the four race groups (Asians, blacks, Native Americans, and whites), which has been preserved in the bridged and censual population estimates. Race-specific county income was from the 1990 census [29]. NCHS mortality statistics. All deaths occurring in the US are reported to the NCHS, with causes of deaths coded to follow the International Classification of Disease sys- tem. NCHS data also include county of residence (matched to the US census), race, sex, and age. Public-use mortality files, available through the

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0 CHALLENGES AND SUCCESSES IN REDUCING HEALTH DISPARITIES Health-Care Access and Utilization Figure 6A shows self-reported health plan coverage in the eight Ameri- cas. Native Americans in the West (America 5) reported the lowest cover- age, followed by low-income rural southern blacks (America 7). The highest coverage was in northland white low-income rural populations (America 2), followed by Middle America and Asians (Americas 3 and 1). Basic health system encounter, measured as the fraction reporting a routine checkup in the past 12 mo, also shows relatively small variation across the eight Ameri- cas. For both males and females, the rates of routine checkup are slightly higher in Americas 6, 7, and 8, the groups with mortality disadvantage. DISCUSSION The eight Americas in this paper consist of distinct subgroups of the US population defined based on a small number of sociodemographic and geographical indicators including race, the location of the county of resi- dence, population density, race-specific county-level per capita income, and cumulative homicide rate. Put in a global context, the disparities in mortal- ity experiences among the eight Americas, each consisting of millions or tens of millions of Americans, are enormous. The eight Americas analysis indicates that ten million Americans with the best health have achieved one of the highest levels of life expectancy on record, 3 y better than Japan for females and 4 y better than Iceland for males. At the same time, tens of millions of Americans are experiencing levels of health that are more typical of middle-income or low-income developing countries. These poor levels of Figure 6. Health Plan Coverage and Health Service Utilization in the Eight C-6.eps Americas DOI: 10.1371/journal.pmed.0030260.g006 image bitmap

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 APPENDIX C health occur in areas throughout the country. The health disparities among the eight Americas cannot be explained by single causes of death such as homicide or HIV. Nor are the largest sources of disparity in children and the elderly. The mortality disparities are most concentrated in young and middle-aged males and females, and are a result of a number of chronic diseases and injuries with well-established risk factors. Trends in life expectancy show that neither the relative ordering nor the absolute levels of life expectancy disparities among the eight Americas decreased between 1982 and 2001. During the late 1980s and early 1990s, the life expectancy gap between America 8 and the remaining groups widened significantly for males, mostly because of HIV and homicide rates. In this overall picture of stable disparities, there have been specific groups whose mortality has worsened. For example, the life expectancy of low- income white females in Appalachia and the Mississippi Valley declined between 1982 and 2001. The most important limitation of the data used for our analysis is that reported race in the census, used for population estimates, may be differ- ent from race in mortality statistics, where race may be reported by the family, the certifying physician, or the funeral director [1,31]. Sensitivity to differential race reporting would be largest for those groups with small population and a relatively large proportion of mixed-race individuals, mainly the Native Americans and Asians [1,31]. In these groups, it is more likely for race to be reported as Native American or Asian in the census than it is in the death certificate; hence, the differential underestimation of deaths and population results in bias in the form of a net underestimation of mortality [1,31]. The mortality and population for Asians were corrected for differential underestimation, using the National Mortality Followback Survey [1,31] (Correction using the National Longitudinal Mortality Study would have given virtually identical estimates: 12% underreporting of mortality in the National Mortality Followback Survey versus 13% in the National Longitudinal Mortality Study [31]). For Native Americans, mis- reporting race on death certificates is most important where mixed races exist and Native Americans form a small proportion of the population (e.g., in California). The grouping used in the eight Americas distinguished between those Native Americans who primarily live on or near reservations (America 5) and the remaining Native Americans (included in America 3), and is therefore robust to this error because living on or near reservations increases the likelihood of correct race recording on death certificates. Any residual bias would be in the form of net underestimation of mortality as described above and as observed nationally for Native Americans [31]. Mortality underestimation would in turn imply that life expectancy is even lower in America 5, and hence further magnify the findings of the above analysis on mortality disadvantage in America 5.

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 CHALLENGES AND SUCCESSES IN REDUCING HEALTH DISPARITIES A secondary source of bias for Asians may be back-migration of first- generation immigrants, who return to their home countries due to illness. This would lead to an underreporting of deaths for Asians, and overestima- tion of life expectancy in America 1. To examine the effect of this source of bias, we repeated the analysis restricting the sample to US-born Asians. Excluding the two states (Alaska and Hawaii) whose Asian population is entirely in America 3 (and not in America 1), US-born Asian females and males had life expectancies at birth that were, respectively, 5.1 and 1.6 y higher than those for combined US-born and foreign-born Asians together, consistent with previous findings on immigrant populations [4]. Lower mortality in US-born Asians confirms that the patterns in Figures 3–5 are not a result of unrecorded mortality due to return migration among Asian populations; rather, they represent a real mortality advantage in America 1. The findings on persistent health disparities in the eight Americas raise the question of why, as a society, we have failed to narrow health gaps between distinct and large subgroups of the US population. Opportunities and interventions to reduce health inequalities include (1) reducing socio- economic inequalities, which are the distal causes of health inequalities, (2) increasing financial access to health care by decreasing the number of Americans without health plan coverage, (3) removing physical, behav- ioral, and cultural barriers to health care, (4) reducing disparities in the quality of care, (5) designing public health strategies and interventions to reduce health risks at the level of communities (e.g., changes in urban/ neighborhood design to facilitate physical activity and reduce obesity), and (6) designing public health strategies to reduce health risks that target individuals or population subgroups that are not necessarily in the same community (e.g., tobacco taxation or pharmacological interventions for blood pressure and cholesterol). Important research in the past few decades has illustrated the critical role of individual and community-level socioeconomic factors, be it in abso- lute or relative terms, in health outcomes [11,24,37,38]. In addition to (or in the absence of, as is currently the case in the US) systematic policies for reducing socioeconomic inequalities, public health and health care provide instruments for addressing inequalities in health outcomes. Much of the health policy agenda in the US is currently focused on health insurance coverage for the nearly 44 million Americans (15% of the population) who lack health insurance [39,40]. Although increasing insurance coverage and access to care would most likely contribute to narrowing disparities across the eight Americas, the available data (Figure 6) suggest that the variation in health plan coverage across the eight Americas is small relative to the very large gradient in health outcomes. It is likely that expanding insurance coverage alone would still leave huge disparities in young and middle-aged

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 APPENDIX C adults. A shortcoming of the BRFSS data on health insurance and health- care utilization, however, is that they do not provide any insight into the likely contribution of variation in quality of care to the disparities across the eight Americas. The diseases with the largest contribution to mortality disparities across the eight Americas are chronic diseases and injuries with well-established risk factors, including alcohol use, tobacco smoking, overweight and obesity, and elevated blood pressure, cholesterol, and glucose. These risk factors are also the leading cause of burden of disease in the nation as a whole (Figure 7). An important question, therefore, is the distributions of exposure to these risks in the eight Americas, and the fraction of disease- specific and all-cause mortality attributable to their hazardous effects. This is particularly relevant for combinations of risk factors that together account for large proportions of many chronic diseases [41,42]. Definite estimates of the contributions of risk factors to health inequalities require analyses for race-county combinations, which are not readily possible using currently available data: among data sources on risk factors, the BRFSS allows subnational analysis but relies on self-reported exposure. Although self-reported exposure is the common metric for risks such as tobacco smoking and alcohol use, it is subject to bias for overweight and obesity and for elevated blood pressure, cholesterol, and glucose because of individual reporting behavior and because individuals may not be aware of their blood pressure, cholesterol, and glucose status. The National Health and Nutri- tion Examination Survey provides measurements of this latter group of risks, but does not include sufficient geographical detail for analysis at the county or even state level [25]. Methods for combining the two data sources to obtain estimates for population subgroups based on race and place of residence are required [43]. If analysis of risk factors illustrates that a sub- stantial proportion of disparities among the eight Americas are attributable to risk factor exposure, risk factor interventions should be investigated as tools for reducing health inequalities, in the same way that they have been used for achieving aggregate national health benefits. The interventions will likely include both population-wide measures (e.g., tobacco taxation, drinking-and-driving countermeasures, and interventions to reduce public and domestic alcohol-induced violence) and personal interventions (e.g., pharmacological interventions for blood pressure and cholesterol). The traditional emphasis of the US health system has been on children and the elderly, as, for example, illustrated by the low levels of resources devoted to injury prevention and tobacco control compared with immu- nization [44]. This emphasis may have partly contributed to substantially lower disparities in these age groups relative to young and middle-aged adults. On the other hand, the emphasis on children and the elderly has treated many of the diseases that are important contributors to young

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 CHALLENGES AND SUCCESSES IN REDUCING HEALTH DISPARITIES Figure 7. Burden of Disease Attributable to the Ten Leading Risk Factors in the very-low-mortality countries of the Region of Americas C-7.eps The estimates refer to the Global Burden of Disease epidemiological region that bitmap image of this region’s population includes Canada, Cuba, and the US [45]; more than 85% live in the US and most data sources apply to the US. DOI: 10.1371/journal.pmed.0030260.g007 and middle-aged adult health disparities, and their risk factors, as either the responsibilities of individuals (alcohol, tobacco, obesity, and dietary determinants of blood pressure and cholesterol, like salt) or in the domain of clinical care (blood pressure and cholesterol). A number of important steps are needed to broaden the current perspective. First, there is a need to use systematic epidemiological and economic analyses to identify effec- tive and cost-effective health interventions—whether targeting populations or individuals—that would make the biggest difference to those with the worst health. Given the distinct epidemiological, geographical, and socio- demographic profiles of the eight Americas, the leading interventions may be different for each, although some common core strategies may exist (e.g., common core cardiovascular disease prevention strategies). Second, monitoring systems should be developed by the states and territories to

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 APPENDIX C provide local but benchmarked information on the fraction of the popula- tion in each community who would benefit from these interventions and are receiving them. Third, information on the delivery of these interventions for different communities should be publicly reported. It is when the public, community and professional groups, media, and politicians focus attention on what is being achieved, and why efforts are working in some places and not others, that the culture of accountability for health outcomes will be strengthened. SUPPORTING INFORMATION Dataset S1. Life Expectancy at Birth by County Found at 10.1371/journal.pmed.0030260.sd001 (4 MB XLS). Figure S1. Geographic Locations for Americas 2, 3, and 4 Found at 10.1371/journal.pmed.0030260.sg001 (549 KB PDF). Figure S2. Geographic Locations for Americas 6, 7, and 8 Found at 10.1371/journal.pmed.0030260.sg002 (268 KB PDF). ACKNOWLEDGMENTS We thank J. Holt, J. Marks, M. McKenna, G. Mensah, and J. Salomon for valuable discussions and comments. Author contributions. CJLM and ME designed the study. SCK, CM, NT, MTB, and TJI analyzed data and constructed figures and maps. CJLM, SCK, and ME wrote the paper. REFERENCES 1. Hahn RA, Eberhardt S (1995) Life expectancy in four U.S. racial/ethnic populations: 1990. Epidemiology 6: 350–355. 2. Wong MD, Shapiro MF, Boscardin WJ, Ettner SL (2002) Contribution of major diseases to disparities in mortality. N Engl J Med 347: 1585–1592. 3. Singh GK, Yu SM (1996) Trends and differentials in adolescent and young adult mortal- ity in the United States, 1950 through 1993. Am J Public Health 86: 560–564. 4. Singh GK, Miller BA (2004) Health, life expectancy, and mortality patterns among im- migrant populations in the United States. Can J Public Health 95: 14–21. 5. Cooper R, Cutler J, Desvigne-Nickens P, Fortmann S, Friedman L, et al. (2000) Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: Findings of the national conference on cardiovascular disease prevention. Circulation 102: 3137–3147. 6. Navarro V (1990) Race or class versus race and class: Mortality differentials in the United States. Lancet 336: 1238–1240. 7. Geronimus AT, Bound J, Waidmann TA, Hillemeier MM, Burns PB (1996) Excess mortal- ity among blacks and whites in the United States. N Engl J Med 335: 1552–1558.

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 CHALLENGES AND SUCCESSES IN REDUCING HEALTH DISPARITIES 44. Centers for Disease Control and Prevention (2005) FY 2005 CDC appropriation—Budget by functional area. Available: http://www.cdc.gov/fmo/PDFs/FY05FundFunctAreaTable. pdf. Accessed 21 July 2006. 45. Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJL, et al. (2002) Selected major risk factors and global and regional burden of disease. Lancet 360: 1347–1360. EDITORS’ SUMMARY Background It has been recognized for a long time that the number of years that people in the United States can expect to live (‘‘life expectancy’’) varies enormously. For example, white Americans tend to live longer than black Americans, and life expectancy is much greater in some of the roughly 3,000 counties of the US than it is in others. However, there is a lack of informa- tion and understanding on how big a part is played in ‘‘health inequalities’’ by specific diseases and injuries, by risk factors (such as tobacco, alcohol, and obesity), and by variations in access to effective health care. Why Was This Study Done? The researchers wanted to find a way of dividing the people of the US into groups based on a small number of characteristics—such as location of county of residence, race, and income—that would help demonstrate the most important factors accounting for differences in life expectancy. What Did the Researchers Do and Find? The researchers used figures from the US Census Bureau and the National Center for Health Statistics to calculate mortality (death) rates for the years 1982–2001. They took note of the county of residence and of the race of all the people who died during that period of time. This enabled them to calculate the mortality rates for all 8,221 ‘‘race-county units’’ (all of the individuals of a given race in a given county). They experimented with different ways of combining the race-counties into a small and manage- able number of groups. They eventually settled on the idea of there being ‘‘eight Americas,’’ defined on the basis of race-county, population density, income, and homicide rate. Each group contains millions or tens of millions of people. For each of the eight groups the researchers estimated life expec- tancy, the risk of mortality from specific diseases, the proportion of people who had health insurance, and people’s routine encounters with health-care services. (The researchers also created maps of life expectancies for the US counties.) They describe their eight Americas as follows: Asians, northland

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 APPENDIX C low-income rural whites, Middle America, low-income whites in Appala- chia and the Mississippi Valley, western Native Americans, black Middle America, low-income southern rural blacks, and high-risk urban blacks. Many striking differences in life expectancy were found between the eight groups. For example, in 2001, the life expectancy gap between the 3.4 million high-risk urban black males and the 5.6 million Asian females was nearly 21 years. Within the sexes, the life expectancy gap between the best-off and the worst-off groups was 15.4 years for males (Asians versus high-risk urban blacks) and 12.8 years for females (Asians versus low- income rural blacks in the South). The causes of death that were mainly responsible for these variations were various chronic diseases and injury. The gaps between best-off and worst-off were similar in 2001 to what they were in 1987. What Do These Findings Mean? Health inequalities in the US are large and are showing no sign of reducing. Social and economic reforms would certainly help change the situation. At the same time, the public health system should also improve the way in which it deals with risk factors for chronic diseases and injuries so that groups with the highest death rates receive larger benefits. Additional Information Please access these Web sites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.0030260. • A Perspective article by Gregory Pappas in this issue of PLoS Medi- cine (DOI: 10.1371/journal.pmed.0030357) discusses the methods of this piece of research and the findings • The American Medical Students’ Association deals with the ques- tion ‘‘What are Health Disparities?’’ on its web site • The National Institutes of Health’s ‘‘Strategic Research Plan to Reduce and Ultimately Eliminate Health Disparities’’ may be seen at the NIH web site • The Office of Minority Health at the Centers for Disease Control and Prevention has a Web page called ‘‘Eliminating Racial and Ethnic Health Disparities’’ • The issue of health inequalities in the US has also been dealt with by the Robert Wood Johnson Foundation

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