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Biographies ROGENE F. HENDERSON, Chairman, Subcommittee on Pulmonary Toxicology, is a senior scientist and supervisor of the Chemistry and Biochemical Toxicology Group at the Lovelace Inhalation Toxicology Research Institute in Albuquerque, New Mexico. She has done extensive research on the analysis of bronchoalveolar ravage fluid to evaluate lung injury in animal toxicology studies. She has also headed studies on the disposition and metabolic fate of inhaled vapors to aid in planning and interpretation of long-term carcinogenicity studies in rodents. Dr. Henderson has been a member of the Committee on Toxicology of the Board on Environmental Studies and Toxicology of the National Research Council since 1985. MARIE AMORUSO is an assistant professor in the Department of Environmental and Community Medicine at University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and a member of the faculty of the joint graduate program in toxicology, medical school and Rutgers University. She is a toxicologist whose major research interests have been in health effects of air pollutants. Her research has focused on mechanisms of oxidant damage in cell membranes and the effects of the oxidant air pollutants ozone and nitrogen dioxide on alveolar macrophage membrane structure and function. She is also a co-principal investigator in studies on the bioavailability of dioxin and its transpulmonary absorption from lung tissue and is developing new models for risk assessment of pulmonary toxicants. ARNOLD R. BRODY is senior scientist and head of the Pulmonary Pathology Laboratory, National Institute of Environmental Health Sciences. He received an M.S. from the University of Illinois in 1967 and a Ph.D. from Colorado State University in 1969, and he held a post doctoral position at Ohio State University in 1969-1972. Dr. Brody is an adjunct professor in the Department of Pathology, graduate school faculty, and curriculum in toxicology of Duke University College of Medicine. He also holds an adjunct appointment in the graduate school faculty and curriculum in toxicology of the University of North Carolina, Chapel Hill. EDWARD D. CRANDALL is chief of the Division of Pulmonary and Critical Care Medicine and Bruce Webster Professor of Internal Medicine at the New York Hospital, Cornell Medical Center, New York, New York. He won a research career development award from NIH in 1975. 167

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168 CORERS IN PULMONARY TOXICOLOGY Dr. Crandall is a member of the American College of Physicians, the American Thoracic Society, the American Society for Clinical Investigation, the American Physiological Society, and the American Institute of Chemical Engineering. His research interests are in lung epithelial transport, pulmonary physiology and disease, pulmonary gas exhange, and cell membrane structure and function. JAMES D. CRAPO is a professor of medicine and associate professor of pathology at Duke University Medical Center. He received his M.D. degree from the University of Rochester in 1971. He served an internship in internal medicine at Harvard General Hospital in Torrence, California, and a residency in internal medicine followed by a fellowship in pulmonary medicine at Duke University Medical Center. He served as a staff associate at the National Institute of Environmental Health Sciences from 1972 to 1975. In 1976 Dr. Crapo joined the faculty at Duke University Medical Center, where he has served as chief of the Division of Allergy, Critical Care and Respiratory Medicine since 1979. His research interests involve the use of biochemical, immunocytochemical, and ultrastructural techniques to evaluate the effects of free radicals in causing acute lung injury and to determine the effects of exposure to common environmental pollutants on pulmonary structure and function. RONALD P. DANIELE is professor of medicine and pathology at the Hospital of the University of Pennsylvania. His principal research interests are in the immune inflammatory mechanisms of the lung and their role in mediating pulmonary interstitial lung diseases, in particular acute and chronic lung injury produced by inhaled inorganic agents, such as silica and beryllium. He has studied the effects of those agents in both humans and experimental models. He was one of the first to use bronchoalveolar ravage as an investigative tool for the study of interstitial lung diseases. Dr. Daniele is director of the Pulmonary Immunology Laboratory at the University of Pennsylvania Medical School. He is on the editorial board of Experimental Lung Research and is associate editor of the Journal of A pplied Physiology. In addition to serving on advisory committees of the National Research Council and the Environmental Protection Agency, he is a member of the Pulmonary Diseases Advisory Committee of the National Heart, Lung, and Blood Institute. CARL FRANZBLAU is a professor and chairman of the Department of Biochemistry at Boston University School of Medicine. He received his Ph.D. in biochemistry from the Albert Einstein College of Medicine in 1962. His research interests are focused on connective- tissue biochemistry and its relation to pulmonary disease. ALLEN G. HARMSEN is an assistant scientist at the Trudeau Institute in Saranac Lake New York. He received his Ph.D. in immunobiology from Iowa State University in 1979. He was a postdoctoral fellow at Vermont Lung Center in 1979-1981, assistant professor of biology at New Mexico Institute of Mining and Technology in 1981-1984, and staff scientist at Lovelace Inhalation Toxicology Research Institute in 1984-1986. His current research interests include lung defense mechanisms in the compromised host. Dr. Harmsen belongs to the Reticuloendothelial Society and the American Society for Microbiology. GARY W. HUNNINGHAKE is a professor of medicine and director of the Division of Pulmonary Medicine at the University of Iowa College of Medicine. His basic research interests are in the molecular mechanisms of lung injury in patients with asthma and interstitial lung disease. He has also pioneered the use of bronchoalveolar ravage in clinical and research studies in patients with those disorders. He received his M.D. degree and his training in internal medicine from the TIniv~r~itv Of Kanaac ~ (~' 1~,;~^ 1~^ he spent 3 years as a clinical associate in the National Institute of Allergy and Infectious Diseases and then joined the National Heart, Lung, and Blood Institute as a senior investigator before joining the faculty at the University of Iowa. He has served as ~ ~^ I. Al L~1 It 1_~ll~a~

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BIOGRAPHIES 169 president of the American Federation for Clinical Research and is a member of the American Society for Clinical Investigation and the Association of American Physicians. He has also served as a member of the administrative board of the Council of Academic Societies of the Association of American Medical Societies and has served on several NIH study sections. PHILIP J. LANDRIGAN is a professor of community medicine and director of the Division of Environmental and Occupational Medicine of the Mount Sinai School of Medicine, New York, New York. He obtained his medical degree from the Harvard Medical School in 1967. He completed an internship at Cleveland Metropolitan General Hospital in 1967-1968 and he completed a residency in pediatrics at the Children's Hospital Medical Center, Boston, Massachusetts, in 1968-1970. He is board-certified in pediatrics. From 1970 through 1985, Dr. Landrigan served as a commissioned officer in the U. S. Public Health Service. In 1985, he assumed his present post at the Mount Sinai School of Medicine, where he is responsible for directing a research program in environmental and occupational medicine, for the training of residents, and for the teaching of medical students and he is a professor of pediatrics. JOE L. MAUDERLY is president of Lovelace Biomedical and Environmental Research Institute and director of the Inhalation Toxicology Research Institute, Albuquerque, New Mexico. He received his doctorate in veterinary medicine from Kansas State University in 1967 and served in the U.S. Air Force at the U.S. Army Natick Laboratories, Natick, Massachusetts, during 1967-1969. He joined the Inhalation Toxicology Research Institute in 1969 as a respiratory physiologist. His primary research interests have been in the effects of inhaled toxic materials on respiratory function and lung structure. He has worked to adapt human respiratory function measurements for use with animals and has studied the usefulness of animal respiratory function data for predicting potential health effects in humans. He has focused primarily on cause-effect relationships between structural and functional changes in the lung. His interests also encompass pulmonary carcinogenesis from inhaled complex materials, animal models of human lung diseases, clinical applications of lung function measurements, influences of age and sex on lung structure and function, and research management. ROBERT A. ROTH is a professor in the Department of Pharmacology and Toxicology at Michigan State University. He received his Ph.D. in 1975 from Johns Hopkins University. He was a toxicological screening specialist with the U.S. Army Environmental Hygiene Agency in 1969-1971 and a research fellow at Yale University in 1975-1977. He has been at Michigan State University since 1977. Dr. Roth is a member of the American Society for Pharmacology and Experimental Therapeutics, a member of the Society of Toxicology, a diplomats of the American Board of Toxicology, and a member of the NIH Toxicology Study Section. He received the NIH merit award for 1988-1998. Dr. Roth's research interests include mechanisms of lung and liver injury from toxic chemicals and physiologic and toxicologic influences on drug metabolism. RICHARD B. SCHLESINGER is a professor of environmental medicine at New York University School of Medicine, New York, New York, and director of the Systemic Toxicology Program and Laboratory of Pulmonary Biology and Toxicology, Institute of Environmental Medicine, NYU Medical Center. He received his Ph.D. in 1975 from New York University. Dr. Schlesinger was the recipient of the Kenneth Morgareidge Award for contributions to the field of toxicology in 1987 and of a research career development award from the National Institute of Environmental Health Sciences in 1983. Dr. Schlesinger served on the Environmental Protection Agency Science Advisory Board Extrapolation Models Subcommittee and the National Council on Radiation Protection and Measurements Respiratory Tract Modelling Task Group and was a Consultant to EPA for an issue paper on acid aerosols,

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170 MARKERS IN PULMONARY TOXICOLOGY state-of-the-science report on direct health effects of air pollutants associated with acidic precursor emissions, and the nitrogen oxides criteria document. He is on the editorial boards of Inhalation Toxicology and Fundamental and Applied Toxicology. Dr. Schlesinger is vice-president-elect of the Inhalation Specialty Section, Society of Toxicology, and is a member of the Technical Committee, Society of Toxicology. FRANK E. SPEIZER is a professor of medicine at Harvard Medical School, professor of environmental science at Harvard School of Public Health, and co-director of the Channing Laboratory, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachussetts. He received his M.D. from Stanford University Medical School in 1960. His research interests include epidemiologic studies of chronic diseases associated with environmental exposure, particularly heart and lung disease and cancer. MARK I. UTELL is a professor of medicine and toxicology at the University of Rochester School of Medicine and co-director of the pulmonary disease unit. He also serves as co-director of the occupational health program at the medical school. He received his M.D. from Tufts University School of Medicine in 1972 and his training in pulmonary medicine training at the University of Rochester. His research interests have focused on the pulmonary effects of inhaled environmental pollutants. He serves as a member of the Research Committee of the Health Effects Institute and is a member of the Clean Air Scientific Advisory Committee of the Environmental Protection Agency. He has been an ad hoc member of several NIH study sections and EPA review committees.