. "Letter Report." Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants: Letter Report. Washington, DC: The National Academies Press, 2008.
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Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants: Letter Report
TABLE 8 Incidence of Malaria During Prophylactic Effect 1 (Period of 35 Days After Dose at 3 Months)
Location, Country
Ifakara, Tanzania
Navrongo, Ghana
Manhiça, Mozambique
Kumasi, Ghana
Lambaréné, Gabon
Tamale, Ghana
Placebo
Episodes
10
45
41
44
5
17
PYAR
30
98
55
48
48
53
Incidence
0.33
0.46
0.75
0.92
0.10
0.32
IPTi with SP
Episodes
2
10
17
8
2
6
PYAR
30
98
57
49
48
55
Incidence
0.07
0.10
0.30
0.16
0.04
0.11
Efficacy (95% CI)
80 (9, 96)
78 (52, 90)
60 (29, 77)
82 (62, 92)
75 (−240, 98)
83 (13, 97)
p-value
0.038
<0.001
0.002
<0.001
0.29
0.034
NOTE: PYAR: Person-years at risk.
SOURCE: Reprinted with permission from the Statistical Working Group (IPTi Consortium, 2007b).
TABLE 9 Incidence of Malaria During Prophylactic Effect 2 (Period of 35 Days After Dose at 9 Months)
Location, Country
Ifakara, Tanzania
Navrongo, Ghana
Manhiça, Mozambique
Kumasi, Ghana
Lambaréné, Gabon
Tamale, Ghana
Placebo
Episodes
23
147
33
53
10
30
PYAR
25
107
49
40
40
51
Incidence
0.92
1.4
0.67
1.3
0.25
0.58
IPTi with SP
Episodes
2
33
10
25
6
5
PYAR
26
107
51
41
40
53
Incidence
0.08
0.31
0.20
0.61
0.15
0.09
Efficacy (95% CI)
92 (64, 98)
78 (67, 84)
71 (41, 86)
54 (27, 72)
42 (−78, 82)
96 (85, 99)
p-value
0.001
<0.001
0.001
0.001
0.34
<0.001
NOTE: PYAR: Person-years at risk.
SOURCE: Reprinted with permission from the Statistical Working Group (IPTi Consortium, 2007b).
