TABLE 10 Incidence of Malaria During the Inter-Dose 1 Perioda

Location, Country

Ifakara, Tanzania

Navrongo, Ghana

Manhiça, Mozambique

Kumasi, Ghana

Lambaréné, Gabon

Tamale, Ghana

Placebo

Episodes

47

464

142

248

32

241

PYAR

99

580

184

184

173

200

Incidence

0.47

0.80

0.77

1.4

0.19

1.0

IPTi with SP

Episodes

29

412

154

219

28

166

PYAR

102

578

194

184

173

201

Incidence

0.28

0.71

0.80

1.2

0.16

0.83

Efficacy (95% CI)

42 (−1, 67)

11 (−8, 26)

−2 (−37, 24)

11 (−6, 26)

14 (−56, 53)

19 (−1, 35)

p-value

0.055

0.23

0.88

0.19

0.61

0.064

NOTE: PYAR: Person-years at risk.

a The Inter-dose 1 period extends from 35 days after (a) dose 2 (age 3 months) in Ifakara; (b) dose 2 (age 4 months) in Navrongo and Manhiça; (c) dose 1 (age 3 months) in Kumasi, Lambaréné, and Tamale until the next dose of IPTi administered at 9 months of age.

SOURCE: Reprinted with permission from the Statistical Working Group (IPTi Consortium, 2007b).



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