. "Letter Report." Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants: Letter Report. Washington, DC: The National Academies Press, 2008.
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Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants: Letter Report
TABLE 14 Incidence of Hospital Admission with Malaria Parasites from Randomization Up to 5 Months After the Last Dose of SP
Location, Country
Ifakara, Tanzania
Navrongo, Ghana
Manhiça, Mozambique
Kumasi, Ghana
Lambaréné, Gabon
Tamale, Ghana
Overall
Placebo
Episodes
52
91
79
35
38
16
PYAR
310
1401
628
710
561
717
Incidence
0.17
0.06
0.13
0.05
0.07
0.02
IPTi with SP
Episodes
27
58
69
38
44
10
PYAR
309
1405
634
709
580
709
Incidence
0.09
0.04
0.11
0.05
0.08
0.01
Efficacy (95% CI)
49 (15, 70)
36 (10, 55)
15 (−21, 40)
−9 (−72, 31)
−12 (−75, 28)
37 (−43, 72)
21 (−2, 38)
p-value
0.009
0.011
0.37
0.73
0.61
0.27
0.066
NOTE: PYAR: Person-years at risk. The committee used Stata to calculate the overall efficacy and its 95 percent confidence limit.
SOURCE: Data from the Report of the Statistical Working Group (IPTi Consortium, 2007b).
TABLE 15 Incidence of All-Cause Hospital Admissions from Randomization Up to 5 Months After the Last Dose of SP
Location, Country
Ifakara, Tanzania
Navrongo, Ghana
Manhiça, Mozambique
Kumasi, Ghana
Lambaréné, Gabon
Tamale, Ghana
Overall
Placebo
Episodes
172
445
359
94
NA
73
PYAR
303
1400
632
710
NA
714
Incidence
0.57
0.32
0.57
0.13
NA
0.10
IPTi with SP
Episodes
138
397
298
92
NA
49
PYAR
303
1405
637
709
NA
707
Incidence
0.46
0.25
0.47
0.13
NA
0.07
Efficacy (95% CI)
20 (−3, 38)
11 (−6, 26)
24 (7, 38)
2 (−30, 27)
NA
33 (0, 55)
18 (9, 27)
p-value
0.09
0.20
0.01
0.89
NA
0.05
0.001
NOTE: NA: Not available; PYAR: Person-years at risk. The committee used Stata to calculate the overall efficacy and its 95 percent confidence limit.
SOURCE: Data from the Report of the Statistical Working Group (IPTi Consortium, 2007b).
