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Suggested Citation:"Appendix E Reviewers." Institute of Medicine. 2008. Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants: Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/12180.
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Page 79

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Appendix E Reviewers This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: PHILIP ADONGO, Navrongo Health Research Centre PATRICK DUFFY, Seattle Biomedical Research Institute STEPHEN L. HOFFMAN, Sanaria Inc. PETER KAZEMBE, Lilongwe Central Hospital MARK KLINE, Texas Children’s Hospital RAMANAN LAXMINARAYAN, Resources for the Future MIKE SOTO, Georgetown University ANDY STERGACHIS, University of Washington School of Public Health and Community Medicine CATHERINE M. WILFERT, Elizabeth Glaser Pediatric AIDS Foundation Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations nor did they see the final draft of the report before its release. The review of this report was overseen by ELENA O. NIGHTINGALE, Scholar- in-Residence, Institute of Medicine, HAROLD C. SOX, Annals of Internal Medicine, and EDWARD B. PERRIN, University of Washington (emeritus). Appointed by the National Research Council and the Institute of Medicine, they were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution. 79

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Intermittent Preventive Treatment for Malaria in Infants (IPTi) is a new strategy which aims to combine the short-term protection of chemoprophylaxis with the long-term protection of naturally-acquired immunity to reduce morbidity from malaria infections during infancy. The Bill and Melinda Gates Foundation requested that the Institute of Medicine (IOM) conduct an independent assessment of the IPTi efficacy studies using sulfadoxine-pyrimethamine (IPTi-SP) that have been previously conducted by the IPTi Consortium. The IOM convened a committee to evaluate the evidence concerning IPTi-SP, which included addressing issues related to its utility and safety, as well as program management aspects of IPTi. The resulting letter report contains the findings, conclusions, and recommendations of the IOM committee. Overall, the committee found that the evidence presented makes IPTi-SP a promising public health strategy to diminish the morbidity from malaria infections, especially for the incidence of clinical malaria, among infants at high risk who reside in areas of high- or moderate-intensity transmission and is worthy of continued investment. The committee also cautioned that during large-scale implementation problems such as drug supply and logistics; monitoring and resistance; and community acceptance and reaction to IPTi-SP could arise. To maximize the greatest public health impact, the committee advised that these issues would best be addressed in an appropriate local context.

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