the relevant regulations and the guide and must receive appropriate training before beginning work.

The Animal Welfare Act and the Policy on the Humane Care and Use of Laboratory Animals both require institutions to have Institutional Animal Care and Use Committees (IACUCs), which include experts in the care of animals and members of the public. These committees review and approve research proposals using animals, oversee animal care programs and facilities, and respond to concerns about the use of animals in research. Also, private organizations like the American Association for the Accreditation of Laboratory Animal Care accredit research institutions using existing regulations and the guide as standards.