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19 LETTER REPORT SUMMARY Overall the committee was encouraged by the progress NASA has made in such a short period of time to develop the first iteration of the evidence books and NASA’s willingness to request this external review early in the program’s history. The committee’s recommendations to strengthen the content, composition, and dissemination of the evidence books are intended, in a fashion similar to recommendations made re- garding the Bioastronautics Roadmap, to improve future versions of these critical documents. These evidence books should be the continu- ously updated knowledge base of best evidence regarding risks to human health associated with spaceflight, particularly spaceflight beyond low Earth orbit and of long duration. Such a knowledge base will serve the interests of mission planners, researchers, and ultimately the individuals who accept those risks in their role as space travelers. Daniel Masys, Chair Committee on NASA’s Research on Human Health Risks Appendix A Meeting Agenda Appendix B Risk Descriptions from the Bioastronautics Roadmap, Pro- gram Requirements Document, and Evidence Books Appendix C Committee Reviews of the Evidence Books REFERENCES Davidson, J. M., A. M. Aquino, S. C. Woodward, and W. W. Wilfinger. 1999. Sustained microgravity reduces intrinsic wound healing and growth factor re- sponses in the rat. FASEB Journal 13(2):325-329. IOM (Institute of Medicine). 2001. Space Passage: Astronaut Care for Explora- tion Missions. Washington, DC: National Academy Press. IOM. 2004. Review of NASA’s Longitudinal Study of Astronaut Health. Wash- ington, DC: The National Academies Press.
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20 REVIEW OF NASA’S HUMAN RESEARCH PROGRAM EVIDENCE BOOKS IOM. 2006. A Risk Reduction Strategy for Human Exploration of Space: A Re- view of NASA’s Bioastronautics Roadmap. Washington, DC: The National Academies Press. IOM. 2007. Review of NASA’s Space Flight Health Standards-Setting Process: Letter Report. Washington, DC: The National Academies Press. NASA. 2008a. Human Research Program Requirements Document, February 2008. Houston, TX. NASA. NASA. 2008b. Human Research Program Evidence Book. Houston, TX. NASA. Radek, K. A., L. A. Baer, J. Eckhardt, L. A. DiPietro, and C. E. Wade. 2008. Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing. Journal of Applied Physiology 104(5):1295-1303. Wilson, J. W., C. M. Ott, K. Honer zu Bentrup, R. Ramamurthy, L. Quick, S. Porwollik, P. Cheng, et al. 2007. Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. Proceedings of the National Academy of Sciences (U.S.A.) 104(41):16299-16304.