Eligible Population

Type of Study or Methods

Date(s) of Enrollment

Subgroup (n=Eligible Subjects)

Contacted or Located (% of Eligible)

Responded or Enrolled (Response Rate)


Walker’s Studies of Head-Injured World War II Veterans

Walker and Erculei, 1969

Head-injured men wounded in World War II who were studied at Cushing General Hospital in Framingham, MA, in 1945–1946 (experienced at least one posttraumatic epileptic seizure) or were identified through Army and VA pension rosters as part of followup in Baltimore in 1950–1954 (unselected)


Group 1 (Cushing General Hospital, Framingham, MA): enrolled 1945–1946 (n = 241)


Of 364 men originally identified, information obtained on 343 (94%)

313 (of 343 men, 21 refused to participate, 30 died)

No external comparison—all comparisons between those with and without posttraumatic seizures


Group 2 (Baltimore group): enrolled 1950–1954 (n = 123)


Baltimore group was matched in class and severity of injury









Study Design

Population (where appropriate)




Enrolled (Response Rate)

Walker and Erculei, 1969

Posttraumatic symptoms, including nervousness, headache, irritability, easy fatigability, impaired memory, dizziness, impaired mentation, lack of concentration, insomnia, intolerance to alcohol


313 men examined, questioned for relevant symptoms


Walker and Erculei, 1969

Neurologic deficit


Neurologic deficit assessed with two subgroups of population: patients with no neurologic deficit (n = 50), patients with neurologic deficit (n = 199)


Walker and Erculei, 1969

Socioeconomic status, employment status


Cohort divided into two groups: employed (n = 182), unemployed (n = 121)


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