. "5 MAJOR COHORT STUDIES." Gulf War and Health: Volume 7: Long-Term Consequences of Traumatic Brain Injury. Washington, DC: The National Academies Press, 2008.
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Gulf War and Health, Volume 7: Long-Term Consequences of Traumatic Brain Injury
Reference
Purpose
Study Design
Population (Where Appropriate)
Comments
Eligible
Located
Enrolled(Response Rate)
Levin et al., 1991b
Vegetative state, and consciousness
Prospective
650 patients available for analysis after following exclusions: 167 (16%) had gunshot wounds, 121 (14%) were brain-dead on admission, 92 (12%) were under 16 years old
Levin et al., 1991a
Intracranial hypertension in relation to memory deficits
Prospective
Intracranial pressure recorded at 6-mo followup (n = 149), 1-year followup (n = 132); 133 patients 6 mo after injury, 126 patients 1 year after injury assessed with auditory verbal and nonverbal visual memory tests
Comparison group, normal community residents of Galveston (n = 27) matched on age, education
Chesnut et al., 1993
Early and late hypotension in regards to mortality
Prospective
699 patients available for analysis at time of hospital arrival after following exclusions: 284 were brain-dead on admission, did not survive resuscitation, or had GSW to head; 29 had insufficient information on prehospital course; 18 had insufficient blood-pressure or blood-gas results
Lu et al., 2005
Mortality
Retrospective
635 patients 16–65 years old from TCDB in 1984–1987 (163 with penetrating injury, 76 dead on arrival excluded); 382 from Medical College of Virginia and 822 from clinical-trial databases also included
Reference
Eligible Population
Type of Study orMethods
Date(s) ofEnrollment
Subgroup (n=EligibleSubjects)
Contacted orLocated (%of Eligible)
Responded orEnrolled(ResponseRate)
Comments
Bryant and Harvey Studies
Bryant and Harvey, 1998
222 adults 16–65 years old (mild TBI, no TBI) admitted to major trauma center in New South Wales, Australia after MVA
Prospective
Unspecified 10-mo period
98 had mild TBI
79 (81%) included
At 6 mo, 63 patients captured (80% followup rate)
Exclusion criteria: inability to speak English, PTA > 24 h, not medically fit or on narcotic analgesia other than codeine, inability to be contacted
