Study Design

Population (Where Appropriate)




Enrolled (Response Rate)

Dikmen et al., 1995c

Global outcome, independent living, employment, income, Sickness Impact Profile

Prospective cohort

466 subjects with TBI selected from 3 prospective, longitudinal studies (Behavioral Outcome in Head Injury, Patient Characteristics and Head Injury Outcome, and Dilantin Prophylaxis of Post-Traumatic Seizures)

91% of 514 subjects followed to 1 year after injury Results presented as weighted averages to adjust for differences in eligibility criteria between studies 374 of 418 (89%) followed to 1 year after injury


124 trauma controls who had bodily injury other than to head


88 friend controls, friends of TBI patients, with no pre-existing conditions

Doctor et al., 2005

Employment status

Prospective cohort

418 TBI working before injury from 4 longitudinal investigations enrolled 1980–1994 (Behavioral Outcome in Head Injury, Patient Characteristics and Head Injury Outcome, Dilantin Prophylaxis of Post-Traumatic Seizures, Valproate Prophylaxis of Post-Traumatic Seizures)


Eligible Population

Type of Study or Methods

Date(s) of Enrollment

Subgroup (n= Eligible Subjects)

Contacted or Located (% of Eligible)

Responded or Enrolled (Response Rate)


Roberts (Radcliffe, UK) Studies

Roberts, 1979

548 people (from total population of 7,000) 5–83 years old who sustained TBI and remained unconscious or amnestic > 1 week admitted to Radcliffe Infirmary, Oxford: 479 admitted directly of accident (consecutive series), 69 transfers from Addenbrook Hospital, Cambridge






11 lost to followup, 206 died, leaving 331 surviving patients (291 from consecutive series, 40 from selected series)

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