Reference

Study Design

Population

Type of TBI: Mild, Moderate, Severe; Blunt, Penetrating, Blast

Health Outcomes or Outcome Measures

Results

Adjustments

Comments or Limitations

 

 

additional 10-year period (1975–1984) and followup of original cases (followup of 53,222 person-years)

Moderate: LOC for 30 min–24 h or skull fracture Severe: LOC or amnesia for more than 24 h, subdural hematoma, or brain contusion

 

CI, 1.0–2.2); moderate, SIR, 2.9 (95% CI, 1.9–4.1); severe, SIR, 17.0 (95% CI, 12.3–23.6) Mild: < 1 year, SIR, 3.1 (95% CI, 1.0–7.2); 1–4 years, SIR, 2.1 (95% CI, 1.1–3.8); 5–9 years, SIR, 0.9 (95% CI, 0.3–2.6); ≥ 10 years, SIR, 1.1 (95% CI, 0.5–2.1)

Moderate: < 1 year, SIR, 6.7 (95% CI, 2.4–14.1); 1–4 years, SIR, 3.1 (95% CI, 1.4–6.0); 5–9 years, SIR, 3.0 (95% CI, 1.2–6.2); ≥ 10 years, SIR, 1.8 (95% CI, 0.8–3.6)

Severe: < 1 year, SIR, 95.0 (95% CI, 58.4–151.2); 1–4 years, SIR, 16.7 (95% CI, 8.4–32.0); 5–9 years, SIR, 12.0 (95% CI, 4.5–26.6); ≥ 10 years, SIR, 4.0 (95% CI, 1.1–10.2)

seizure after TBI estimated with Kaplan-Meier method Importance of prognostic factors determined with Cox proportional hazards analysis

whose rates of seizures may be different from adults’ rates

Singer, 2001

Retrospective cohort

Same population as above (4,541 patients) with TBI

Mild head injury: LOC or amnesia for less than 30 min

Seizures determined from medical records

97 of 4,541 TBI cases had at least one seizure in 50-year

 

Included children and adults



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