TABLE 8.3 Psychologic Outcomes—Anxiety Disorder Studies


Study Design


Type of TBI

Health Outcomes or Outcome Measures



Comments or Limitations

Bryant and Harvey, 1999a

Prospective cohort

79 mild TBI (55 males, 24 females), 92 non-TBI patients (61 males, 31 females) 16–65 years old involved in MVAs, consecutively admitted into major trauma hospital for at least 1 day

Mild, defined as PTA for less than 24 h

PTSD diagnosed with CIDI at 6 mo

ISS greater in mild-TBI than in non-TBI group (9.28 vs 4.0; p < 0.001)


Head injury ascertained at time arrived at hospital from MVA





No significant difference in rates of PTSD between groups with mild TBI and no TBI (24%, n, 15; 25%, n, 18, respectively; p value not reported)


Good followup over 6-mo period






Limitations include lack of control for associated injuries, lack of assessment of duration of LOC on occurrence of PTSD



Patients ascertained sequentially over 10-mo period at hospital admission; all assessed at 1 mo; 63 mild TBI (80%), 71 non-TBI (77%) evaluated at 6 mo after trauma






Exclusions: drug or narcotic analgesia (except codeine) for first 4 weeks after injury, inability to answer questions, non-English-speaking






Bryant and Harvey, 1999b

Prospective cohort

46 TBI (32 male, 14 female), 59 non-TBI (31 male, 28 female) involved in MVAs,

Mild TBI with LOC, PTA <24 h

PTSD module from CIDI and PCS checklist

At 6 mo after trauma, 20% of mild-TBI patients, 25.4%


Head injury ascertained at time arrived at hospital from MVA

The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement