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Gulf War and Health, Volume 7: Long-Term Consequences of Traumatic Brain Injury
Additionally, animal models provide the framework for predicting outcomes and developing optimal therapeutics for BINT; however, after reviewing the literature, the committee came to the conclusion that there is a need for more refined animal models of BINT. They should be aligned with emerging data on the human response to BINT. The accessibility to acute clinical data on human BINT from DoD and VA is essential for refining the animal models.
The committee recommends that the Department of Defense and the Departmentof Veterans Affairs support research on animal models of blast-inducedneurotrauma. Consideration should be given to developing models that would berelevant to human traumatic brain injury that encompass a more comprehensiveexperimental design. That could include studies that measure both behavior andpathology that might differ with traumatic brain injury severity. It would beimportant for the Department of Defense and the Department of Veterans Affairsto work with the research community and provide acute clinical data on humanblast-induced neurotrauma to enable refinement of the animal models.
Registry Control Groups
The studies of TBI evaluated by the committee had numerous limitations. A primary limitation results from the nature of the control or comparison group assembled by the investigator. In an attempt to improve the quality of future TBI studies, the committee has described what it considers to be appropriate control groups.
Evaluating whether TBI in service members is associated with particular outcomes requires comparison groups of service members who have experienced injuries other than TBI and service members who have been deployed but not injured. Comparing outcomes of TBI with outcomes in those reference groups is the only means of identifying which outcomes are due solely to TBI and not to deployment or to injury in general.
The committee recommends that the Department of Veterans Affairs include, inthe development of the Traumatic Brain Injury Veterans Health Registry(hereafter referred to as “the registry”), other service members who could providea valid comparison for the analysis of outcomes. Comparison groups should bemade up of injured persons without traumatic brain injury or blast exposure,uninjured deployed veterans, and uninjured nondeployed but previously active-duty veterans. Those groups could be compared with persons who have received adiagnosis of traumatic brain injury and with those who have possible or probabletraumatic brain injury. The three comparison groups should have samples largeenough to provide reference rates of outcomes of interest. Furthermore, theregistry needs to be representative of the traumatic brain injury population to beable to determine associations between such injury and various outcomes. Thereshould be no exclusions on the basis of sex, race, geographic region, or rank.
Access to medical records is essential to ensure the validity of a recommended research design. Neurologic status, computed tomographic or magnetic resonance imaging, electroencephalography, associated nonbrain injuries, and durations of impaired consciousness and PTA amnesia are important for the accurate classification of service members into appropriate groups.