Managing Health Effects of Beryllium Exposure

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Managing Health Effects of Beryllium Exposure (2008)
Board on Environmental Studies and Toxicology (BEST)

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. "5 Genotoxicity and Carcinogenicity." Managing Health Effects of Beryllium Exposure. Washington, DC: The National Academies Press, 2008.

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Managing Health Effects of Beryllium Exposure

TABLE 5-1 Genotoxicity Studies of Beryllium Compounds

Assay or End Point	Species	Compound	With Activation	Without Activation	Reference
In vitro
Plate incorporation assay	Salmonella typhimurium	BeSO₄	Negative	Negative	Rosenkranz and Poirier 1979; Simmon 1979a; Simmon et al. 1979; Dunkel et al.1984; Arlauskas et al. 1985; Ashby et al. 1990
	S. typhimurium	Be(NO₃)₂	Negative	Negative	Arlauskas et al. 1985; Kuroda et al. 1991
	S. typhimurium	BeO	Negative	Negative	Kuroda et al. 1991
	S. typhimurium	BeCl₂	Negative	Negative	Kuroda et al. 1991
	Eschericia coli WP-2 uvrA	BeSO₄	Negative	Negative	Dunkel et al. 1984
Rec assay	Bacillus subtilis	BeSO₄	—	Positive	Kada et al. 1980; Kanematsu et al. 1980
	B. subtilis	BeCl₂	—	Positive	Kuroda et al. 1991
	B. subtilis	BeCl₂	—	Negative	Nishioka 1975
	B. subtilis	Be(N0₃)₂	—	Positive	Kuroda et al. 1991
	B. subtilis	BeO	—	Negative	Kuroda et al. 1991
	E. coli	BeSO₄	—	Positive	Dylevoi 1990
DNA modification	E. coli pol A⁺/A⁻	BeSO₄	—	Negative	Rosenkranz and Poirier 1979
Bioluminescence test	Photobacterium fischeri	BeCl₂	—	Positive	Ulitzur and Barak 1988
Recombogenic activity	Saccharomyces cerevisiae	BeSO₄	Negative	Negative	Simmon 1979b
Host-mediated assay	S. cerevisiae	BeSO₄	—	Negative	Simmon et al. 1979
Host-mediated assay	S. typhimurium	BeSO₄	—	Negative	Simmon et al. 1979