TABLE 5-1 Genotoxicity Studies of Beryllium Compounds

Assay or End Point

Species

Compound

With Activation

Without Activation

Reference

In vitro

Plate incorporation assay

Salmonella typhimurium

BeSO4

Negative

Negative

Rosenkranz and Poirier 1979; Simmon 1979a; Simmon et al. 1979; Dunkel et al.1984; Arlauskas et al. 1985; Ashby et al. 1990

S. typhimurium

Be(NO3)2

Negative

Negative

Arlauskas et al. 1985; Kuroda et al. 1991

S. typhimurium

BeO

Negative

Negative

Kuroda et al. 1991

S. typhimurium

BeCl2

Negative

Negative

Kuroda et al. 1991

Eschericia coli WP-2 uvrA

BeSO4

Negative

Negative

Dunkel et al. 1984

Rec assay

Bacillus subtilis

BeSO4

Positive

Kada et al. 1980; Kanematsu et al. 1980

B. subtilis

BeCl2

Positive

Kuroda et al. 1991

B. subtilis

BeCl2

Negative

Nishioka 1975

B. subtilis

Be(N03)2

Positive

Kuroda et al. 1991

B. subtilis

BeO

Negative

Kuroda et al. 1991

E. coli

BeSO4

Positive

Dylevoi 1990

DNA modification

E. coli pol A+/A

BeSO4

Negative

Rosenkranz and Poirier 1979

Bioluminescence test

Photobacterium fischeri

BeCl2

Positive

Ulitzur and Barak 1988

Recombogenic activity

Saccharomyces cerevisiae

BeSO4

Negative

Negative

Simmon 1979b

Host-mediated assay

S. cerevisiae

BeSO4

Negative

Simmon et al. 1979

S. typhimurium

BeSO4

Negative

Simmon et al. 1979



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