TABLE E-1 Risk Factors for Depression

Developmental Period

Context

Individual

Family

School and Peers

Neighborhood and Community

Preconception/prenatal

Genetic predisposition1,2,3,6

 

 

 

Infancy

Left frontal lobe hypoactivation1,2,5

Difficult temperament, such as negative affect, difficult to soothe, and lower activity1

Insecure attachment1

 

 

 

Early childhood

Dysregulated growth hormone process2,3

Left frontal lobe hypoactivation2,5

Temperament: inhibited, socially reticent and easily upset2,4

Subsyndromal symptoms and dysthymia4

Insecure attachment1

Hostile to peers, socially inhibited4

 

Poor grades/achievement1,3

 



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