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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium (2009)

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. "Polymer Technology for Gene Therapy--Daniel W. Pack." Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium. Washington, DC: The National Academies Press, 2009.

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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium

REFERENCES

Blaese, R.M., K.W. Culver, A.D. Miller, C.S. Carter, T. Fleisher, M. Clerici, G. Shearer, L. Chang, Y. Chiang, P. Tolstoshev, J.J. Greenblatt, S.A. Rosenberg, H. Klein, M. Berger, C.A. Mullen, W.J. Ramsey, L. Muul, R.A. Morgan, and W.F. Anderson. 1995. T lymphocyte-directed gene therapy for ADA-SCID: initial trial results after four years. Science 270(5235): 475–480.

Boussif, O., F. Lezoualch, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and J.P. Behr. 1995. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proceedings of the National Academy of Sciences of the United States of America 92(16): 7297–7301.

Cavazzana-Calvo, M., S. Hacein-Bey, G. de Saint Basile, F. Gross, E. Yvon, P. Nusbaum, F. Selz, C. Hue, S. Certain, J.L. Casanova, P. Bousso, F.L. Deist, and A. Fischer. 2000. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288(5466): 669–672.

Felgner, P.L., and A. Rolland. 1998. Non-viral gene delivery systems. Advanced Drug Delivery Reviews 30(1-3): 1–3.

Forrest, M.L., J.T. Koerber, and D.W. Pack. 2003. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. Bioconjugate Chemistry 14(5): 934–940.

Forrest, M.L., G.E. Meister, J.T. Koerber, and D.W. Pack. 2004. Partial acetylation of polyethylenimine enhances in vitro gene delivery. Pharmaceutical Research 21(2): 365–371.

Gabrielson, N.P., and D.W. Pack. 2006. Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions. Biomacromolecules 7(8): 2427–2435.

Green, J.J., R. Langer, and D.G. Anderson. 2008. A combinatorial polymer library approach yields insight into nonviral gene delivery. Accounts of Chemical Research 41(6): 749–759.

Kay, M.A., C.S. Manno, M.V. Ragni, P.J. Larson, L.B. Couto, A. McClelland, B. Glader, A.J. Chew, S.J. Tai, R.W. Herzog, V. Arruda, F. Johnson, C. Scallan, E. Skarsgard, A.W. Flake, and K.A. High. 2000. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nature Genetics 24(3): 257–261.

Khuri, F.R., J. Nemunaitis, I. Ganly, J. Arseneau, I.F. Tannock, L. Romel, M. Gore, J. Ironside, R.H. MacDougall, C. Heise, B. Randlev, A.M. Gillenwater, P. Bruso, S.B. Kaye, W.K. Hong, and D.H. Kirn. 2000. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nature Medicine 6(8): 879–885.

Lim, Y.-B., C.-H. Kim, K. Kim, S.W. Kim, and J.-S. Park. 2000. Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-l-glycolic acid]. Journal of the American Chemical Society 122(27): 6524–6525.

Pack, D.W., A.S. Hoffman, S. Pun, and P.S. Stayton. 2005. Design and development of polymers for gene delivery. Nature Reviews. Drug Discovery 4(7): 581–593.

Smith, J., Y. Zhang, and R. Niven. 1997. Toward development of a non-viral gene therapeutic. Advanced Drug Delivery Reviews 26(2-3): 135–150.

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Wu, G.Y., and C.H. Wu. 1987. Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. Journal of Biological Chemistry 262(10): 4429–4432.

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Front Matter (R1-R12)
DRUG DELIVERY SYSTEMS, Introduction--William J. Grieco and Efrosini Kokkoli (1-4)
Recent Developments in Needle-Free Drug Delivery--Samir Mitragotri (5-16)
Targeted Polymeric Nanotherapeutics--Jeff Hrkach (17-24)
Polymer Technology for Gene Therapy--Daniel W. Pack (25-32)
Traceable Drug Delivery: Lighting the Way with Qdots--Xiaohu Gao (33-40)
EMERGING NANOELECTRONIC DEVICES, Introduction--Jia Chen and Victor Zhirnov (41-44)
The Quest for the Next Information-Processing Technology--Jeffrey J. Welser (45-52)
Molecular and Polymer Nanodevices--Nikolai Zhitenev (53-58)
Roll Printing of Crystalline Nanowires for Integrated Electronic and Sensor Arrays--Ali Javey, Zhiyong Fan, Johnny C. Ho, and Roie Yerushalmi (59-70)
The Role of DNA in Nanoarchitectonics--Mihrimah Ozkan and Cengiz S. Ozkan (71-82)
COGNITIVE ENGINEERING, Introduction (83-86)
Cognitive Engineering: It's Not What You Think--Stephanie Guerlain (87-92)
Driving Attention: Cognitive Engineering in Designing Attractions and Distractions--John D. Lee (93-102)
Human Reliability Analysis in Cognitive Engineering and System Design--Ronald Laurids Boring (103-110)
Cognitive Engineering Applications in Health Care--Ann M. Bisantz (111-122)
UNDERSTANDING AND COUNTERING THE PROLIFERATION OF WEAPONS OF MASS DESTRUCTION, Introduction--J. Scott Goldstein and Gregory A. Hebner (123-126)
U.S. National Security in New Times--Steven D. Nixon (127-132)
Combating Weapons of Mass Destruction: Translating Strategic Guidance into Actionable Solutions--Charles L. Beames (133-140)
Nuclear Deterrence in the 21st Century: The Role of Science and Engineering--Joseph C. Martz and Jonathan S. Ventura (141-146)
Energy Policy and the Role of Technology in National Security--A.D. Romig, Jr. with Arnold B. Baker (147-158)
Contributors (159-168)
Program (169-172)
Participants (173-182)